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Superoxide Dismutase 2/SOD2 抗体 (B-1): sc-133254

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说明书
  • Superoxide Dismutase 2/SOD2抗体(B-1)是小鼠单克隆IgG2b κ, 在26篇文献中引用,规格为200 µg/ml
  • 免疫human物种的代表全长SOD-2的氨基酸1-222
  • 推荐用于 mouse, rat 和 human 来源的SOD-2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 Superoxide Dismutase 2/SOD2 (E-10): sc-137254,可查看有标记的 Superoxide Dismutase 2/SOD2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 2b BP-HRP">m-IgG2b BP-HRP和m-IgGκ BP-HRP是Superoxide Dismutase 2/SOD2 Antibody (B-1) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与Superoxide Dismutase 2/SOD2 Antibody (B-1) 打包提供(请参阅下面的订购信息)。
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関連項目

超氧化物歧化酶家族由三种金属酶(SOD-1、SOD-2和SOD-3)组成,可催化活性氧(ROS)如超氧阴离子的氧化还原。SOD-2前体是一种由核染色质编码的222个氨基酸的蛋白质,在细胞质中合成并在翻译后导入线粒体基质。与作为同源二聚体细胞质Cu-Zn酶的SOD-1不同,SOD-2是一种同源四聚体锰酶(也称为MnSOD),在线粒体中发挥作用。ROS涉及广泛的退行性过程,包括阿尔茨海默病、帕金森病和缺血性心脏病。缺乏SOD-2的纯合突变小鼠表现出扩张型心肌病、肝脏和骨骼肌中脂质积聚、代谢性酸中毒、氧化性DNA损伤以及心脏和骨骼肌中的呼吸链缺陷。SOD-2基因的多态性也与人类的非家族性、特发性扩张型心肌病有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Superoxide Dismutase 2/SOD2 抗体 (B-1) 参考文献:

  1. 线粒体功能障碍和神经变性中的SOD2。  |  Flynn, JM. and Melov, S. 2013. Free Radic Biol Med. 62: 4-12. PMID: 23727323
  2. MWCNTs诱导人间皮细胞ROS的产生、ERK的磷酸化以及SOD-2的表达。  |  Yu, M., et al. 2016. Int J Toxicol. 35: 17-26. PMID: 26111538
  3. 炎症介导的 SOD-2 上调有助于黄曲霉毒素 G1 诱导的肺腺癌的上皮-间质转化和肿瘤细胞迁移。  |  Yi, L., et al. 2017. Sci Rep. 7: 7953. PMID: 28801561
  4. 解读SOD2在镰状细胞疾病中的作用。  |  Dosunmu-Ogunbi, AM., et al. 2019. Blood Adv. 3: 2679-2687. PMID: 31506286
  5. ESAT-6通过SOD-2调节自噬反应,从而诱导牛分枝杆菌BCG的细胞内存活。  |  Yabaji, SM., et al. 2020. Biochim Biophys Acta Proteins Proteom. 1868: 140470. PMID: 32535275
  6. 血管钙化中的超氧化物歧化酶2(SOD2):关注血管平滑肌细胞、钙化发病机理和治疗策略。  |  Tsai, YT., et al. 2021. Oxid Med Cell Longev. 2021: 6675548. PMID: 33728027
  7. 小鼠体内SOD2表达降低不会影响朊病毒的病程或病理。  |  Foliaki, ST., et al. 2021. PLoS One. 16: e0259597. PMID: 34735539
  8. 内源性SOD2(超氧化物歧化酶)调节衰老过程中血小板依赖性凝血酶生成和血栓形成。  |  Sonkar, VK., et al. 2023. Arterioscler Thromb Vasc Biol. 43: 79-91. PMID: 36325902
  9. 线粒体超氧化物歧化酶Sod2在氧化应激期间抑制核基因组的不稳定性。  |  Gupta, SV., et al. 2023. Genetics. 225: PMID: 37638880
  10. 烟酰胺核糖甙通过调节 SIRT3/SOD2 信号通路减轻心肌缺血再灌注损伤  |  Zhao, K., et al. 2024. Biomed Pharmacother. 175: 116689. PMID: 38703508

订购信息

产品名称产品编号规格价格数量收藏夹

Superoxide Dismutase 2/SOD2 抗体 (B-1)

sc-133254
200 µg/ml
$322.00

Superoxide Dismutase 2/SOD2 (B-1): m-IgGκ BP-HRP 套装

sc-534609
200 µg Ab; 40 µg BP
$361.00

Superoxide Dismutase 2/SOD2 (B-1): m-IgG2b BP-HRP 套装

sc-549271
200 µg Ab; 10 µg BP
$361.00

I am using SOD-2 (B-1): sc-133254 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Professor Griffin
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by huazi20 from good resultThe level of SOD expression in 4 patients with nephrotic syndrome was detected by thisantibody. The results of WB showed that the expression level of SOD protein was obviouslyhigh. After 1:1000 dilution, the result shows no background and he signal is very strong.
Date published: 2017-09-10
Rated 5 out of 5 by Mzhi from Great antibodyWe use this antibody for years, diluted 1:500 samples detected a clear band!
Date published: 2017-05-10
Rated 5 out of 5 by Canyoyo from Perfect bandsGood clean signal in our WB, It's helpful to our research.I would recommend to others.
Date published: 2017-04-07
Rated 5 out of 5 by MRS CHEN from very good!great antibody for WB,strong band with little background!
Date published: 2016-12-09
Rated 5 out of 5 by S_K_ from Excellent results even at high dilutionExcellent results even at high dilution
Date published: 2015-11-13
Rated 5 out of 5 by NZ from Produced excellent immunoperoxidase stainingProduced excellent immunoperoxidase staining of the basement membrane and cytoplasmic staining in formalin fixed, paraffin-embedded human prostate tissue. -SCBT QC
Date published: 2015-05-01
Rated 5 out of 5 by HC from Strong signal in WB in human SODStrong signal in WB in human SOD-2 transfected 293T, HeLa, DU 145 and T98G whole cell lysates. -SCBT QC
Date published: 2015-04-11
Rated 5 out of 5 by SS from Published data for WB in human PC3 cellsPublished data for WB in human PC3 cells. -SCBT Publication Review
Date published: 2015-04-01
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Superoxide Dismutase 2/SOD2 抗体 (B-1) is rated 4.9 out of 5 by 11.
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