Superoxide Dismutase 1/SOD1 Antibody (C-8): sc-515404

SOD-1 Antibody (C-8) is a mouse monoclonal IgG3 kappa light chain antibody that detects SOD-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SOD-1 antibody (C-8) is available in a non-conjugated form, specifically designed for researchers studying Cu-Zn superoxide dismutase-1 (SOD-1) in various biological contexts. SOD-1 (C-8) monoclonal antibody recognizes a crucial cytosolic enzyme that acts as a scavenger of superoxide radicals, converting them into less harmful hydrogen peroxide and molecular oxygen, thereby protecting cells from oxidative stress. This enzymatic function is vital for maintaining cellular health, particularly in tissues with high metabolic activity, where reactive oxygen species can accumulate and cause damage. SOD-1 is predominantly located in the cytoplasm and functions as a homodimer, which is essential for stability and activity. Mutations in the SOD-1 gene have been linked to severe neurodegenerative conditions, including familial amyotrophic lateral sclerosis (ALS), where the loss of zinc-binding capability leads to decreased protective function, resulting in increased neurotoxicity and motor neuron degeneration. Understanding SOD-1 and its interactions with other cellular components is critical for developing therapeutic strategies against these debilitating diseases.

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Superoxide Dismutase 1/SOD1 Antibody (C-8) References:

1. Cells from individuals with SOD-1 associated familial amyotrophic lateral sclerosis do not have an increased susceptibility to radiation-induced free radical production or DNA damage.  |  Mithal, NP., et al. 1999. J Neurol Sci. 164: 89-92. PMID: 10385054
2. Altered calcium homeostasis in spinal motoneurons but not in oculomotor neurons of SOD-1 knockout mice.  |  Siklós, L., et al. 2000. Acta Neuropathol. 99: 517-24. PMID: 10805095
3. GDNF is trophic for mouse motoneurons that express a mutant superoxide dismutase (SOD-1) gene.  |  Derby, ML., et al. 2000. Amyotroph Lateral Scler Other Motor Neuron Disord. 1: 113-22. PMID: 11467048
4. Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome.  |  Gulesserian, T., et al. 2001. J Neural Transm Suppl. 71-84. PMID: 11771762
5. SOD-1 inhibits FAS expression in cortex of APP transgenic mice.  |  Chen, Z., et al. 2005. Apoptosis. 10: 499-502. PMID: 15909112
6. Exercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed rats.  |  de Moraes, C., et al. 2008. BMC Physiol. 8: 12. PMID: 18510739
7. The presence of SOD 1 and GSH-Px in bovine retained and properly released foetal membranes.  |  Kankofer, M., et al. 2013. Reprod Domest Anim. 48: 699-704. PMID: 23398331
8. Respiratory sensitizer hexamethylene diisocyanate inhibits SOD 1 and induces ERK-dependent detoxifying and maturation pathways in dendritic-like cells.  |  Silva, A., et al. 2014. Free Radic Biol Med. 72: 238-46. PMID: 24742817
9. The Long-Term Algae Extract (Chlorella and Fucus sp) and Aminosulphurate Supplementation Modulate SOD-1 Activity and Decrease Heavy Metals (Hg++, Sn) Levels in Patients with Long-Term Dental Titanium Implants and Amalgam Fillings Restorations.  |  Merino, JJ., et al. 2019. Antioxidants (Basel). 8: PMID: 31014007
10. Shorter axon initial segments do not cause repetitive firing impairments in the adult presymptomatic G127X SOD-1 Amyotrophic Lateral Sclerosis mouse.  |  Bonnevie, VS., et al. 2020. Sci Rep. 10: 1280. PMID: 31992746

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Superoxide Dismutase 1/SOD1 Antibody (C-8) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Superoxide Dismutase 1/SOD1 Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Superoxide Dismutase 1/SOD1 Antibody (C-8) Specifications

Alternate Product Name: SOD1

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 30-53

Epitope Target: SOD-1

Epitope Species: human

Product Reactivity/Detection: SOD-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Superoxide Dismutase 1/SOD1 Antibody (C-8): P: Blocking Peptide

The preferred Superoxide Dismutase 1/SOD1 antibody is Superoxide Dismutase 1/SOD1 Antibody (B-1): sc-271014.