SmcX Antibody (C-1): sc-365860
- SmcX Antibody (C-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1462-1560 mapping at the C-terminus of SmcX of human origin
- recommended for detection of SmcX of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-365860 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SmcX Antibody (C-1) for WB applications. This reagent is now offered in a bundle with SmcX Antibody (C-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SEE ALSO...
SmcX Antibody (C-1) is a mouse monoclonal IgG1 antibody that detects SmcX in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SmcX, also known as JARID1C, MRXJ, KDM5C, or XE169, is a crucial nuclear protein that plays a significant role in the regulation of gene expression and chromatin dynamics. Anti-SmcX antibody (C-1) recognizes a protein containing one ARID domain, one JmjC domain, one JmjN domain, and two PHD-type zinc fingers, classifying SmcX within the JARID1 histone demethylase family. SmcX is predominantly expressed in the brain and skeletal muscle, where SmcX functions as a histone demethylase, specifically targeting lysine residues on Histone H3 to remove methyl groups. This demethylation is vital for maintaining the histone code, which influences transcriptional regulation and chromatin remodeling. SmcX interacts with iron and α-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, effectively repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are linked to X-linked mental retardation (XLMR), a condition that results in cognitive impairment and reduced IQ. The presence of multiple isoforms of SmcX, arising from alternative splicing events, further underscores the complexity and significance of SmcX in cellular processes. SmcX monoclonal antibody (C-1) is an essential tool for researchers investigating the intricate roles of SmcX in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SmcX Antibody (C-1) | sc-365860 | 200 µg/ml | $322.00 | |||
SmcX Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-552366 | 200 µg Ab; 40 µg BP | $361.00 | |||
SmcX Antibody (C-1) X | sc-365860 X | 200 µg/0.1 ml | $322.00 |