Date published: 2025-9-9

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SLMAP 抗体 (B-9): sc-393336

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说明书
  • SLMAP 抗体 B-9 是小鼠单克隆 IgG1 (kappa轻链),SLMAP抗体,规格为200 µg/ml
  • 免疫原氨基酸序列606-828位于human物种的SLMAP的C-terminus
  • SLMAP 抗体 (B-9) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 SLMAP
  • 抗SLMAP抗体(B-9)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取SLMAP (B-9): sc-393336免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP是SLMAP Antibody (B-9) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与SLMAP Antibody (B-9) 打包提供(请参阅下面的订购信息)。

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    SLMAP抗体(B-9)是一种IgG1 κ小鼠单克隆SLMAP抗体(也称为SLMAP抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的SLMAP蛋白。SLMAP抗体(B-9)既可以是非偶联的抗SLMAP抗体形式,也可以是多种偶联形式的抗SLMAP抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。SLMAP(肌纤维膜结合蛋白)是一种IV型单次跨膜蛋白,由828个氨基酸组成。在非复制细胞中,SLMAP位于肌纤维膜上,在肌肉组织分裂的过程中,它以依赖微管的方式重新定位到中心体。SLMAP参与蛋白质-蛋白质相互作用,在成肌细胞融合中发挥作用。作为同源二聚体内在膜蛋白,SLMAP有两个亮氨酸拉链,这形成了77个氨基酸组成的卷曲螺旋结构,还含有一个叉头相关(FHA)结构域。卷曲螺旋结构对于调控神经递质的释放、N型钙通道和膜融合很重要,FHA结构域则参与细胞核信号传导。可变剪接SLMAP可产生八种异构体。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    SLMAP 抗体 (B-9) 参考文献:

    1. 编码肌小球相关蛋白(SLAPs)基因 3' 区域的交替剪接, 表达和基因组结构定义了一类新型卷尾锚定膜蛋白。  |  Wielowieyski, PA., et al. 2000. J Biol Chem. 275: 38474-81. PMID: 10986292
    2. Syntaxin:一种突触蛋白,与突触前活性区突触小泡的对接有关。  |  Bennett, MK., et al. 1992. Science. 257: 255-9. PMID: 1321498
    3. 一类具有 C 端锚的膜蛋白。  |  Kutay, U., et al. 1993. Trends Cell Biol. 3: 72-5. PMID: 14731773
    4. 布鲁加达综合征的新疾病基因:肌膜相关蛋白基因突变会损害hNav1.5的细胞内运输。  |  Ishikawa, T., et al. 2012. Circ Arrhythm Electrophysiol. 5: 1098-107. PMID: 23064965
    5. SAV1 通过颉颃 PP2A 磷酸酶 STRIPAK 的作用促进 Hippo 激酶的活化。  |  Bae, SJ., et al. 2017. Elife. 6: PMID: 29063833
    6. STK25 通过调节 SAV1-STRIPAK 拮抗作用抑制 Hippo 信号传导。  |  Bae, SJ., et al. 2020. Elife. 9: PMID: 32292165
    7. 对程序性细胞死亡10的致癌作用进行泛癌分析。  |  Sun, N., et al. 2022. J Oncol. 2022: 1242658. PMID: 36276268
    8. 接受放射治疗的分次照射大鼠和乳腺癌患者的DNA甲基化改变。  |  Sallam, M., et al. 2022. Int J Mol Sci. 23: PMID: 36555856
    9. 对结直肠癌恶性增殖中RNA结合蛋白SRSF2依赖性可变剪接标志的全面分析。  |  Liu, W., et al. 2023. J Biol Chem. 299: 102876. PMID: 36623729
    10. 心脏祖细胞中肌细胞膜相关蛋白3(SLMAP3)的缺失会延迟心肌的胚胎生长,但不会影响Hippo通路。  |  Rehmani, T., et al. 2024. Int J Mol Sci. 25: PMID: 38474134
    11. 骨骼肌中 E-C 耦合单元的结构和发展。  |  Franzini-Armstrong, C. and Jorgensen, AO. 1994. Annu Rev Physiol. 56: 509-34. PMID: 8010750
    12. 肌膜相关蛋白的分子克隆, 表达和染色体分配。与膜相关的酸性两性α-螺旋蛋白家族。  |  Wigle, JT., et al. 1997. J Biol Chem. 272: 32384-94. PMID: 9405447

    订购信息

    产品名称产品编号规格价格数量收藏夹

    SLMAP 抗体 (B-9)

    sc-393336
    200 µg/ml
    $316.00

    SLMAP (B-9): m-IgG Fc BP-HRP 套装

    sc-550762
    200 µg Ab; 10 µg BP
    $354.00

    SLMAP (B-9): m-IgGκ BP-HRP 套装

    sc-550760
    200 µg Ab; 40 µg BP
    $354.00

    SLMAP 抗体 (B-9) AC

    sc-393336 AC
    500 µg/ml, 25% agarose
    $416.00

    SLMAP 抗体 (B-9) HRP

    sc-393336 HRP
    200 µg/ml
    $316.00

    SLMAP 抗体 (B-9) FITC

    sc-393336 FITC
    200 µg/ml
    $330.00

    SLMAP 抗体 (B-9) PE

    sc-393336 PE
    200 µg/ml
    $343.00

    SLMAP 抗体 (B-9) Alexa Fluor® 488

    sc-393336 AF488
    200 µg/ml
    $357.00

    SLMAP 抗体 (B-9) Alexa Fluor® 546

    sc-393336 AF546
    200 µg/ml
    $357.00

    SLMAP 抗体 (B-9) Alexa Fluor® 594

    sc-393336 AF594
    200 µg/ml
    $357.00

    SLMAP 抗体 (B-9) Alexa Fluor® 647

    sc-393336 AF647
    200 µg/ml
    $357.00

    SLMAP 抗体 (B-9) Alexa Fluor® 680

    sc-393336 AF680
    200 µg/ml
    $357.00

    SLMAP 抗体 (B-9) Alexa Fluor® 790

    sc-393336 AF790
    200 µg/ml
    $357.00

    I am wondering what is the SLMAP isoform 1,2,3,4,5&8 mentioned on datasheet of the antibody sc-393336? (I've cheeked UniProt and NCBI: UniProt lists 8 isoforms but there are not quite in the region 606-828; while NCBI only list 7 isoforms.)

    Asked by: Xiaoman
    Thank you for your question. The isoform reactivity that is described for this antibody, SLMAP (B-9): sc-393336, is based on the Uniprot protein sequence. Please see the link below as a reference. This mouse monoclonal antibody is raised against amino acids 606-828 mapping at the C-terminus of SLMAP of human origin. However, because the exact epitope recognized by this antibody has not been determined, we can not guarantee that the antibody will be able to recognize each of these predicted isoforms. We will update our product information and remove the specified isoform reactivity for this clone. http://www.uniprot.org/uniprot/Q14BN4#sequences
    Answered by: Technical Support
    Date published: 2017-08-25

    I need to use an antibody to detect the protein in samples of monkey origin. Do you know if sc-393336: SLMAP (B-9) mouse monoclonal antibody will work?

    Asked by: jerojero
    Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
    Answered by: Technical Support
    Date published: 2017-03-06
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    Rated 4 out of 5 by from Works well in Immunofluorescence, not in WBImmunofluorescence shows clear staining in human and mouse samples. Western Blot has unspecific bands.
    Date published: 2020-01-28
    Rated 5 out of 5 by from Very good Western blot data of SLMAP expressionVery good Western blot data of SLMAP expression in HeLa, A-431 and U-251-MG whole cell lysates. -SCBT QC
    Date published: 2014-05-03
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    SLMAP 抗体 (B-9) is rated 4.5 out of 5 by 2.
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