SLAM Antibody (9D1): sc-59365
- SLAM Antibody (9D1) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against SLAM of mouse origin
- recommended for detection of SLAM of mouse origin by FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SLAM Antibody (9D1). This work is in progress.
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SLAM Antibody (9D1) is a rat monoclonal IgG1 antibody that detects SLAM in mouse samples through flow cytometry (FCM). SLAM, or signaling lymphocyte-activation molecule, plays a crucial role in T cell activation and proliferation by providing a costimulatory signal independent of the CD28 pathway. This unique mechanism enhances T cell expansion during antigen recognition, vital for effective immune defense. SLAM is primarily located on T cell surfaces, where SLAM interacts with ligands on antigen-presenting cells, facilitating communication between these cell types. This interaction promotes T cell activation and influences the overall immune response, making SLAM significant in both adaptive and innate immunity. SLAM-associated protein (SAP) interacts with SLAM, containing an SH2 domain that inhibits SH-PTP2 recruitment to the SLAM docking site, a process regulated by Fyn phosphorylation. Mutations in the SAP gene have been linked to X-linked lymphoproliferative disease (XLP), highlighting SLAM′s importance in maintaining immune system integrity. Anti-SLAM antibody (9D1) serves as an essential tool for researchers studying T cell biology and immune response mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SLAM Antibody (9D1) References:
- The morbillivirus receptor SLAM (CD150). | Tatsuo, H. and Yanagi, Y. 2002. Microbiol Immunol. 46: 135-42. PMID: 12008921
- Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance. | Menard, L., et al. 2014. J Allergy Clin Immunol. 133: 1149-61. PMID: 24373350
- Canine distemper virus isolated from a monkey efficiently replicates on Vero cells expressing non-human primate SLAM receptors but not human SLAM receptor. | Feng, N., et al. 2016. BMC Vet Res. 12: 160. PMID: 27484638
- SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. | Chen, J., et al. 2017. Nature. 544: 493-497. PMID: 28424516
- The SLAM family receptors: Potential therapeutic targets for inflammatory and autoimmune diseases. | Dragovich, MA. and Mor, A. 2018. Autoimmun Rev. 17: 674-682. PMID: 29729453
- Phocine distemper virus uses phocine and other animal SLAMs as a receptor but not human SLAM. | Seki, F., et al. 2020. Microbiol Immunol. 64: 578-583. PMID: 32215955
- SLAM Associated Protein Signaling in T Cells: Tilting the Balance Toward Autoimmunity. | Gartshteyn, Y., et al. 2021. Front Immunol. 12: 654839. PMID: 33936082
- A Survey of Human Gait-Based Artificial Intelligence Applications. | Harris, EJ., et al. 2021. Front Robot AI. 8: 749274. PMID: 35047564
- Feasibility of Tracking Human Kinematics with Simultaneous Localization and Mapping (SLAM). | Laal, S., et al. 2022. Sensors (Basel). 22: PMID: 36502075
- SLAM-family receptors come of age as a potential molecular target in cancer immunotherapy. | Farhangnia, P., et al. 2023. Front Immunol. 14: 1174138. PMID: 37251372
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SLAM Antibody (9D1) | sc-59365 | 200 µg/ml | $322.00 | |||
SLAM Antibody (9D1) FITC | sc-59365 FITC | 200 µg/ml | $336.00 | |||
SLAM Antibody (9D1) PE | sc-59365 PE | 200 µg/ml | $349.00 |