Simvastatin CAS: 79902-63-9
MF: C25H38O5
MW: 418.57
An HMGCR inhibitor and anti-proliferative agent.

Simvastatin (CAS 79902-63-9)

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同义词: Zocor
应用; An HMGCR inhibitor and anti-proliferative agent
CAS号码: 79902-63-9
纯度: ≥98%
分子量: 418.57
分子式: C25H38O5
* 参考分析证明 大量特定数据 (包括水 含量).
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Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC50 ~ 13 µM).


参考文献

1. Nègre-Aminou, P., et al. 1997. Biochim. Biophys. Acta. 1345: 259-268. PMID: 9150246
2. Wójcik, C., et al. 2000. Int. J. Biochem. Cell Biol. 32: 957-965. PMID: 11084375
3. Danesh, F.R., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 8301-8305. PMID: 12048257
4. Blanco-Colio, L.M., et al. 2003. Kidney Int. 63: 12-23. PMID: 12472764
5. Chopra, V., et al. 2007. Cardiovasc Drugs Ther. 21: 161-169. PMID: 17468937
6. Wang, H., et al. 2007. Exp. Neurol. 206: 59-69. PMID: 17521631

物理状态 :
Solid
溶解度 :
Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), water (0.03 mg/l), and methanol.
保存 :
Store at -20° C
沸点 :
~564.9° C at 760 mmHg (Predicted)
密度 :
1.11 g/cm3
折射率 :
n20D 1.53
IC50 :
HES: IC50 = 6.5 nM; HMG-CoA reductase: IC50 = 3 nM
pK值 :
pKa: 13.49
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
2
RTECS :
EK7798000
PubChem CID :
54454
默克索引 :
14: 8539
MDL 号码 :
MFCD00072007

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PMID: # 16613856  Jeon, E.J. et al. 2006. J. Biol. Chem. 281: 16502-16511.

Patino, W et al. 2005. Proc. Natl. Acad. Sci. USA. 102: 3423-3428.

PMID: # 12504826  Hernández-Presa, MA. et al. 2003. Cardiovasc. Res. 57: 168-177.

PMID: # 12406854  Nishimura, T. et al. 2002. Am. J. Respir. Crit. Care Med. 166: 1403-1408.

PMID: # 11815421  Wilson, SH. et al. 2002. Circulation. 105: 415-418.

1999. Science. 286: 1946-1949.

Yokoyama, K et al. 1998. J. Biol. Chem. 273: 26497 - 26505.

PMID: # 31612028  Oncol Lett. 18: 5173-5184.

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