Senktide CAS: 106128-89-6
MF: C40H55N7O11S
MW: 841.97
A tachykinin NK-3 receptor agonist.

Senktide (CAS 106128-89-6)

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应用; A tachykinin NK-3 receptor agonist
CAS号码: 106128-89-6
纯度: ≥95%
分子量: 841.97
分子式: C40H55N7O11S
* 参考分析证明 大量特定数据 (包括水 含量).
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Senktide is shown to selectively interact with a tachykinin receptor subtype (SP-N) and can be used in studies to find out the regulation, distribution, and functional role of this receptor. This compound is also reported to be an NK-3R agonist and may cause behavior similar to serotonergic stimulation in murine models. NK-3R (tachykinin NK-3 receptors) have been noted to mediate bronchoconstriction in guinea pig lungs, and activation of these receptors by Senktide has also been shown to induce bronchoconstriction. Furthermore, this agent has demonstrated the ability to induce increased numbers of Fos-LI neurons in numerous regions of the guinea pig brain.


参考文献

1. Laufer, R., et al. 1986. J. Biol. Chem. 261: 10257-10263. PMID: 2426259
2. Stoessl, A.J., et al. 1987. Neurosci. Lett. 80: 321-326. PMID: 2446214
3. Dam, T.V., et al. 1990. Brain Res. 506: 175-179. PMID: 1689199
4. Corboz, M.R., et al. 2010. Exp. Lung Res. 36: 509-521. PMID: 20939761

物理状态 :
Solid
顺序 :
Succinyl-Asp-Phe-(N-Me)-Phe-Gly-Leu-Met-NH2
溶解度 :
Soluble in methanol (25 mg/ml), ethanol (25 mg/ml), and DMSO (25 mg/ml).
保存 :
Store at -20° C
沸点 :
1262.64° C at 760 mmHg
密度 :
1.29 g/cm3
折射率 :
n20D 1.58
IC50 :
Tachykinin receptor 3: EC5050 = 0.5 nM (rat); NK3 receptor: EC5050 = 3 nM (human); NK3 receptor: IC50 = 0.02 µM (human); achykinin receptor 3: IC50 = 0.01 µM (guinea pig)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
108147
SMILES :
CC(C)C[[email protected]@H](C(=O)N[[email protected]@H](CCSC)C(=O)N)NC(=O)CNC(=O)[[email protected]](CC1=CC=CC=C1)N(C)C(=O)[[email protected]](CC2=CC=CC=C2)NC(=O)[[email protected]](CC(=O)O)NC(=O)CCC(=O)O

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