Sec31A Antibody (H-2): sc-376587
- Sec31A Antibody (H-2) is a mouse monoclonal IgG2a κ Sec31A antibody, cited in 9 publications, provided at 200 µg/ml
- raised against amino acids 429-571 mapping within an internal region of Sec31A of human origin
- Sec31A Antibody (H-2) is recommended for detection of Sec31A of human origin by WB, IP, IF and ELISA
- Anti-Sec31A Antibody (H-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Sec31A Antibody (H-2) for WB applications. These reagents are now offered in bundles with Sec31A Antibody (H-2) (see ordering information below).
Sec31A Antibody (H-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Sec31A of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Sec31A antibody (H-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sec31A, also known as ABP125, ABP130, or SEC31L1, is a 1,220 amino acid protein characterized by seven WD repeats, which are structural motifs that typically form a tertiary propeller configuration. These WD repeats are crucial for Sec31A′s role in the COP II (coat protein II) complex, where Sec31A is essential for forming transport vesicles from the endoplasmic reticulum and selecting cargo molecules for transport. Proper functioning of Sec31A maintains cellular homeostasis through vesicular trafficking, which is critical for transporting proteins and lipids within cells. Chromosomal aberrations involving Sec31A have been linked to inflammatory myofibroblastic tumors, indicating potential involvement in carcinogenesis. Multiple isoforms of Sec31A exist due to alternative splicing, highlighting regulatory potential in various cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Sec31A Antibody (H-2) References:
- Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport. | Tang, BL., et al. 2000. J Biol Chem. 275: 13597-604. PMID: 10788476
- Secretory protein trafficking and organelle dynamics in living cells. | Lippincott-Schwartz, J., et al. 2000. Annu Rev Cell Dev Biol. 16: 557-89. PMID: 11031247
- Three ways to make a vesicle. | Kirchhausen, T. 2000. Nat Rev Mol Cell Biol. 1: 187-98. PMID: 11252894
- Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor. | Panagopoulos, I., et al. 2006. Int J Cancer. 118: 1181-6. PMID: 16161041
- Structure of the Sec13/31 COPII coat cage. | Stagg, SM., et al. 2006. Nature. 439: 234-8. PMID: 16407955
- The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A. | Yamasaki, A., et al. 2006. Mol Biol Cell. 17: 4876-87. PMID: 16957052
- Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development. | Townley, AK., et al. 2008. J Cell Sci. 121: 3025-34. PMID: 18713835
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sec31A Antibody (H-2) | sc-376587 | 200 µg/ml | $322.00 | |||
Sec31A Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-529908 | 200 µg Ab; 10 µg BP | $361.00 | |||
Sec31A Antibody (H-2): m-IgGκ BP-HRP Bundle | sc-523020 | 200 µg Ab, 40 µg BP | $361.00 | |||
Sec31A Antibody (H-2): m-IgG2a BP-HRP Bundle | sc-547399 | 200 µg Ab; 10 µg BP | $361.00 | |||
Sec31A Antibody (H-2) AC | sc-376587 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Sec31A Antibody (H-2) HRP | sc-376587 HRP | 200 µg/ml | $322.00 | |||
Sec31A Antibody (H-2) FITC | sc-376587 FITC | 200 µg/ml | $336.00 | |||
Sec31A Antibody (H-2) PE | sc-376587 PE | 200 µg/ml | $349.00 | |||
Sec31A Antibody (H-2) Alexa Fluor® 488 | sc-376587 AF488 | 200 µg/ml | $364.00 | |||
Sec31A Antibody (H-2) Alexa Fluor® 546 | sc-376587 AF546 | 200 µg/ml | $364.00 | |||
Sec31A Antibody (H-2) Alexa Fluor® 594 | sc-376587 AF594 | 200 µg/ml | $364.00 | |||
Sec31A Antibody (H-2) Alexa Fluor® 647 | sc-376587 AF647 | 200 µg/ml | $364.00 | |||
Sec31A Antibody (H-2) Alexa Fluor® 680 | sc-376587 AF680 | 200 µg/ml | $364.00 | |||
Sec31A Antibody (H-2) Alexa Fluor® 790 | sc-376587 AF790 | 200 µg/ml | $364.00 |