Date published: 2026-7-30

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Safflower Yellow

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Alternate Names:
Carthamine
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Safflower Yellow, registered under CAS number 36338-96-2, is a natural pigment derived from the petals of the safflower plant (Carthamus tinctorius). This compound is a water-soluble flavonoid, specifically a complex of chalcones that are responsible for its vivid yellow coloration. In research, Safflower Yellow has been utilized extensively in studies investigating its role as a natural dye in various applications, including its incorporation into food products as a colorant and its use in the textile industry for dyeing fabrics. The mechanisms of action of Safflower Yellow primarily involve its interaction with proteins and other macromolecules, where it binds to create stable, brightly colored complexes. This interaction is crucial in studies aimed at understanding the binding efficiency and stability of natural dyes compared to synthetic alternatives, as well as their behavior under different environmental conditions such as pH and temperature. Additionally, Safflower Yellow has been studied in the context of its photostability, which is essential for determining its suitability and longevity as a colorant in materials exposed to light. Researchers also explore the kinetics of its degradation processes to improve the formulation of more durable dye products and applications in industries seeking sustainable and biodegradable color solutions.


Safflower Yellow References

  1. Safflower yellow inhibits angiotensin II-induced adventitial fibroblast proliferation and migration.  |  Liu, Y., et al. 2014. J Pharmacol Sci. 126: 107-14. PMID: 25231558
  2. Safflower Yellow regulates microglial polarization and inhibits inflammatory response in LPS-stimulated Bv2 cells.  |  Yang, XW., et al. 2016. Int J Immunopathol Pharmacol. 29: 54-64. PMID: 26634402
  3. Safflower yellow reduces lipid peroxidation, neuropathology, tau phosphorylation and ameliorates amyloid β-induced impairment of learning and memory in rats.  |  Ma, Q., et al. 2015. Biomed Pharmacother. 76: 153-64. PMID: 26653563
  4. The Mechanism by Which Safflower Yellow Decreases Body Fat Mass and Improves Insulin Sensitivity in HFD-Induced Obese Mice.  |  Zhu, H., et al. 2016. Front Pharmacol. 7: 127. PMID: 27242533
  5. Effects of safflower yellow on beta-amyloid deposition and activation of astrocytes in the brain of APP/PS1 transgenic mice.  |  Shi, XM., et al. 2018. Biomed Pharmacother. 98: 553-565. PMID: 29288971
  6. Safflower yellow promotes angiogenesis through p-VHL/ HIF-1α/VEGF signaling pathway in the process of osteogenic differentiation.  |  Tang, Z., et al. 2018. Biomed Pharmacother. 107: 1736-1743. PMID: 30257392
  7. Safflower Yellow Improves Synaptic Plasticity in APP/PS1 Mice by Regulating Microglia Activation Phenotypes and BDNF/TrkB/ERK Signaling Pathway.  |  Pang, J., et al. 2020. Neuromolecular Med. 22: 341-358. PMID: 32048142
  8. Intragastric safflower yellow and its main component HSYA improve leptin sensitivity before body weight change in diet-induced obese mice.  |  Lyu, X., et al. 2022. Naunyn Schmiedebergs Arch Pharmacol. 395: 579-591. PMID: 35201390
  9. Structure and emulsifying properties of whey protein isolate: Effect of safflower yellow concentration  |  Chen, W., Li, T., Yu, H., Ma, C., Wang, X., Qayum, A., Hou, J. and Jiang, Z. 2020. LWT. 123: 109079.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Safflower Yellow, 25 g

sc-483526
25 g
$200.00