Date published: 2025-9-7
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Rictor Antibody (1G11) - Western Blotting - Image 354771
Rictor 抗体 (1G11): sc-81538. Ramos (A), Hep G2 (B), SH-SY5Y (C), HeLa (D) 和 SK-BR-3 (E) 全细胞裂解液中 Rictor 表达的 Western 印迹分析.
Rictor Antibody (1G11) - Western Blotting - Image 354771
Rictor 抗体 (1G11): sc-81538. Ramos (A), Hep G2 (B), SH-SY5Y (C), HeLa (D) 和 SK-BR-3 (E) 全细胞裂解液中 Rictor 表达的 Western 印迹分析.
Rictor Antibody (1G11) - Western Blotting - Image 354772
Rictor 抗体 (1G11): sc-81538. 在 NAMALWA (A), NIH/3T3 (B), Neuro-2A (C) 和 PC-12 (D) 全细胞裂解液及人肾上腺组织提取物 (E) 中 Rictor 表达的 Western 印迹分析.
Rictor Antibody (1G11) - Western Blotting - Image 57794
Rictor 抗体 (1G11): sc-81538. 拉莫斯全细胞裂解液中 Rictor 表达的 Western 印迹分析.
Rictor 抗体 (1G11): sc-81538. Ramos (A), Hep G2 (B), SH-SY5Y (C), HeLa (D) 和 SK-BR-3 (E) 全细胞裂解液中 Rictor 表达的 Western 印迹分析.

Rictor 抗体 (1G11): sc-81538

4.6(10)
寫評論提問

说明书
  • Rictor 抗体 1G11 是小鼠单克隆 IgG1, 在10篇文献中引用，提供 50 µg/0.5 ml
  • 针对Rictor的human来源的合成肽
  • 推荐用于 mouse, rat 和 human 来源的Rictor WB 和 IP检测
  • 看 Rictor (H-11): sc-271081，可查看有标记的 Rictor 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 关于如何获取Rictor (1G11): sc-81538的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是Rictor Antibody (1G11) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Rictor Antibody (1G11) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

Rictor抗体（1G11）是一种IgG1 κ小鼠单克隆Rictor抗体，可通过WB和IP检测小鼠、大鼠和人类的Rictor。Rictor抗体（1G11）可以是非偶联的抗Rictor抗体形式。FRAP是一种大蛋白激酶，是雷帕霉素的哺乳动物靶点，雷帕霉素是一种免疫抑制剂，可阻止血管再狭窄，并具有潜在的抗癌作用。 FRAP的雷帕霉素不敏感伴侣，也称为Rictor，与D. discoidieum的pianissimo、S. pombe的STE20p和S. cerevisiae的AVO3p具有同源性。Rictor与FRAP形成复合物，这在细胞生长调控中很重要，因为它整合了生长因子和营养来源的信号。Rictor-FRAP复合物在PKCα磷酸化中发挥作用，直接在体外Ser473上磷酸化Akt/PKB，并通过PDK1促进Thr308磷酸化。它还可能作为已丧失PTEN表达的肿瘤的药物靶点，PTEN是一种反对Akt/PKB激活的肿瘤抑制因子。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Rictor 抗体 (1G11) 参考文献:

  1. 体外重组辅助法生成的大小分馏 cDNA 文库的特征。  |  Ohara, O., et al. 2002. DNA Res. 9: 47-57. PMID: 12056414
  2. Rictor是mTOR的一种新型结合伙伴，它定义了一种对雷帕霉素不敏感且不依赖雷帕霉素的调节细胞骨架的途径。  |  Sarbassov, DD., et al. 2004. Curr Biol. 14: 1296-302. PMID: 15268862
  3. 大规模鉴定 HeLa 细胞核磷蛋白。  |  Beausoleil, SA., et al. 2004. Proc Natl Acad Sci U S A. 101: 12130-5. PMID: 15302935
  4. 哺乳动物 TOR 复合物 2 控制肌动蛋白细胞骨架，对雷帕霉素不敏感。  |  Jacinto, E., et al. 2004. Nat Cell Biol. 6: 1122-8. PMID: 15467718
  5. Rictor-mTOR复合体对Akt/PKB的磷酸化和调控。  |  Sarbassov, DD., et al. 2005. Science. 307: 1098-101. PMID: 15718470
  6. S6 激酶 1 的结构决定了是猛禽-mTOR 还是雷克托-mTOR 使其疏水图案位点磷酸化。  |  Ali, SM. and Sabatini, DM. 2005. J Biol Chem. 280: 19445-8. PMID: 15809305
  7. 在 3T3-L1 脂肪细胞中，mTOR.RICTOR 是 Akt/蛋白激酶 B 的 Ser473 激酶。  |  Hresko, RC. and Mueckler, M. 2005. J Biol Chem. 280: 40406-16. PMID: 16221682
  8. 脂肪毒性肝细胞衍生的外泌体微RNA 192-5p通过Rictor/Akt/叉头框转录因子O1信号激活非酒精性脂肪肝中的巨噬细胞  |  Liu, XL., et al. 2020. Hepatology. 72: 454-469. PMID: 31782176
  9. RBM45通过Rictor和ACSL1/ACSL4重新编程脂质代谢，促进肝细胞癌的发生。  |  Wang, C., et al. 2024. Oncogene. 43: 328-340. PMID: 38040804
  10. Rictor介导p53失活，促进肝细胞恶性转化并促进肝癌发生。  |  Wang, C., et al. 2023. J Transl Med. 21: 919. PMID: 38110956
  11. BRAFV600E黑色素瘤细胞中RICTOR/mTORC2的下调可增强对BRAF/MEK抑制的耐受性。  |  Ponzone, L., et al. 2024. Mol Cancer. 23: 105. PMID: 38755661
  12. Rictor/mTORC2信号通过调节BNIP3介导的线粒体自噬，促进肾血管内皮细胞向间充质细胞转化和肾同种异体移植间质纤维化。  |  Feng, D., et al. 2024. Clin Transl Med. 14: e1686. PMID: 38769658

订购信息

产品名称产品编号规格价格数量收藏夹

Rictor 抗体 (1G11)

sc-81538
50 µg/0.5 ml
$316.00

Rictor (1G11): m-IgG Fc BP-HRP 套装

sc-537249
50 µg Ab; 10 µg BP
$354.00

Rictor (1G11): m-IgGκ BP-HRP 套装

sc-534474
50 µg Ab; 40 µg BP
$354.00

Rictor (1G11): m-IgG1 BP-HRP 套装

sc-545105
50 µg Ab; 20 µg BP
$354.00

What is the best secondary to use with sc-81538?

Asked by: Cweed
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 5
Date published: 2017-01-18
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Rated 4 out of 5 by from Work for Western BlotVery clear Western Blot, strong signal and low background. We used it on cancer cell lines.
Date published: 2022-09-02
Rated 4 out of 5 by from good!I tested both rictor antibodies (#271081 and #81538) on Western blot and they were quite specific
Date published: 2020-09-07
Rated 5 out of 5 by from Great westernVery clean western blo data; strong signal, low background
Date published: 2017-02-01
Rated 5 out of 5 by from Great for Western BlotWorks very well in WB, strong signal with a faint background band in some samples that can be used as a loading control.
Date published: 2016-12-29
Rated 5 out of 5 by from Used in IP and worked very wellUsed in IP and worked very well, happy with purchase.
Date published: 2015-06-08
Rated 5 out of 5 by from Produced a clear band with serum starved HeLaProduced a clear band with serum starved HeLa, Hep G2, HEK293, SH-SY5Y, MDCK, PC-12, CMT 93 (G), Neuro 2A (H) and 3T3 (I) whole cell lysates. -SCBT QC
Date published: 2015-06-06
Rated 5 out of 5 by from Clean blot with single strong band at expectedClean blot with single strong band at expected size using Ramos whole cell lysate. -SCBT QC
Date published: 2015-05-10
Rated 5 out of 5 by from Lot B2211 is good for Western BlotLot B2211 is good for Western Blot
Date published: 2015-03-26
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Rictor 抗体 (1G11) is rated 4.6 out of 5 by 10.
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