Rho GDIα Antibody (C-2): sc-374579
- Rho GDIα Antibody (C-2) is a mouse monoclonal IgG1 λ, cited in 1 publications, provided at 200 µg/ml
- raised against a peptide mapping at the C-terminus of Rho GDIα of human origin
- recommended for detection of Rho GDIα of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for Rho GDIα Antibody (C-2) for WB and IHC(P) applications. This reagent is now offered in a bundle with Rho GDIα Antibody (C-2) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Rho GDIα Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects Rho GDIα in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Rho GDIα, also known as ARHGDIA or GDIA1, is a 204 amino acid protein that plays a crucial role in regulating the activity of Rho GTPases, which are essential for numerous cellular processes such as cell migration, adhesion, and cytoskeletal dynamics. By sequestering Rho proteins in their inactive GDP-bound state, Rho GDIα prevents their activation and subsequent signaling, thereby maintaining cellular homeostasis. The importance of Rho GDIα is further underscored by post-translational modification; specifically, phosphorylation at Ser 101 by p21-activated kinase (αPAK). This phosphorylation event inhibits Rho GDIα′s activity, leading to a potential positive feedback loop that enhances the activation of certain Rho GDIα target proteins, which can have significant implications in processes such as cell proliferation and differentiation. Anti-Rho GDIα antibody (C-2) serves as an invaluable tool for researchers studying the intricate signaling pathways mediated by Rho proteins and their regulatory mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rho GDIα Antibody (C-2) | sc-374579 | 200 µg/ml | $322.00 | |||
Rho GDIα Antibody (C-2): m-IgGλ BP-HRP Bundle | sc-522783 | 200 µg Ab, 40 µg BP | $361.00 |