R-(−)-O-Desmethyl Venlafaxine CAS: 142761-11-3
MF: C16H25NO2
R-(−)-O-Desmethyl Venlafaxine is a venlafaxine metabolite.

R-(−)-O-Desmethyl Venlafaxine (CAS 142761-11-3)

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备用名: R)-(−)-4-[2-(Dimethylamino)-1-(1-hydroxycyclo-hexyl)ethyl]phenol; (−)-O-Desmethylvenlafaxine; (R)-(−)-O-Desmethylvenlafaxine;
应用; R-(−)-O-Desmethyl Venlafaxine is a venlafaxine metabolite
CAS号码: 142761-11-3
分子量: 263.38
分子式: C16H25NO2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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R-(−)-O-Desmethyl Venlafaxine is a metabolite of R-Venlafaxine (sc-208209), a selective serotonin noradrenaline reuptake inhibitor. This bicyclic molecule facilitates neurotransmission by preventing presynaptic reuptake, resulting in a higher concentration of neurotransmitters located within the synapse. It is known that the neurotransmitters most effected by this inhibitor are norepinephrine and serotonin, which weakly suppress dopamine at high concentrations. Furthermore, studies show that R-(−)-O-Desmethyl Venlafaxine can be seperated from Venlafaxine using LC-MS/MS in rat plasma.


参考文献

1. Holdcroft, C. 1994. Nurse Pract. 19: 21. PMID: 7816367

2. Holliday, S.M. and Benfield, P. 1995. Drugs. 49: 280-294. PMID: 7729333

3. Shah, G.R., et al. 2009. Anal Sci. 25: 1207-1210. PMID: 19822964

物理状态 :
Solid
溶解度 :
Soluble in ethanol, and methanol.
保存 :
Store at -20° C
熔点 :
>198° C
沸点 :
~403.8° C at 760 mmHg (Predicted)
密度 :
~1.1 g/cm3 (Predicted)
折射率 :
n20D 1.57 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL 号码 :
MFCD04039503
SMILES :
CN(C)C[[email protected]@H](C1=CC=C(C=C1)O)C2(CCCCC2)O

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