Date published: 2025-9-6

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PSR 抗体 (H-7): sc-28348

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说明书
  • PSR 抗体 H-7 是小鼠单克隆 IgG1 κ,PSR抗体, 在32篇文献中引用,规格为200 µg/ml
  • 免疫human物种的PSR的氨基酸1-300
  • PSR 抗体 (H-7) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测 和human 来源的 PSR
  • 抗PSR抗体(H-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取PSR (H-7): sc-28348免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP 是 PSR 抗体 (H-7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与PSR 抗体 (H-7) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

PSR抗体(H-7)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和酶联免疫吸附测定(ELISA)检测人类来源的PSR蛋白。抗磷脂酰丝氨酸受体抗体(H-7)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。磷脂酰丝氨酸受体(PSR)在识别和清除凋亡细胞中起着至关重要的作用,因为PSR与磷脂酰丝氨酸特异性结合,而后者在经历凋亡的细胞外膜上暴露出来。这种相互作用对于巨噬细胞和树突状细胞吞噬死亡细胞至关重要,从而防止炎症并维持组织稳态。PSR主要表达于巨噬细胞、成纤维细胞和上皮细胞表面,在心脏、骨骼肌和肾脏组织中的表达水平较高。此外,PSR广泛糖基化,这可能影响其结合特性和与其他蛋白质的相互作用。PSR在物种间具有保守性,与秀丽隐杆线虫和黑腹果蝇中的蛋白质具有显著同源性,这表明PSR在整个进化过程中在细胞过程中发挥着重要作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PSR 抗体 (H-7) 参考文献:

  1. 磷脂酰丝氨酸在吞噬细胞识别凋亡细胞中的作用。  |  Fadok, VA., et al. 1998. Cell Death Differ. 5: 551-62. PMID: 10200509
  2. 磷脂酰丝氨酸的暴露是巨噬细胞吞噬凋亡淋巴细胞的一个普遍特征。  |  Krahling, S., et al. 1999. Cell Death Differ. 6: 183-9. PMID: 10200565
  3. 果蝇吞噬凋亡细胞需要 croquemort。  |  Franc, NC., et al. 1999. Science. 284: 1991-4. PMID: 10373118
  4. 细胞凋亡逝去,但不会被遗忘。  |  Green, DR. and Beere, HM. 2000. Nature. 405: 28-9. PMID: 10811203
  5. 磷脂酰丝氨酸特异性清除凋亡细胞的受体。  |  Fadok, VA., et al. 2000. Nature. 405: 85-90. PMID: 10811223
  6. 磷脂酰丝氨酸受体蛋白通过多个核定位信号进行核定位。  |  Cui, P., et al. 2004. Exp Cell Res. 293: 154-63. PMID: 14729065
  7. 磷脂酰丝氨酸受体与高密度脂蛋白受体在胸腺哺育细胞识别凋亡细胞的过程中相互配合。  |  Cao, WM., et al. 2004. J Mol Endocrinol. 32: 497-505. PMID: 15072554
  8. 凋亡淋巴细胞表面的磷脂酰丝氨酸会触发巨噬细胞的特异性识别和清除。  |  Fadok, VA., et al. 1992. J Immunol. 148: 2207-16. PMID: 1545126
  9. 磷脂酰丝氨酸与磷脂酰丝氨酸受体之间的相互作用可抑制体内的免疫反应。  |  Hoffmann, PR., et al. 2005. J Immunol. 174: 1393-404. PMID: 15661897
  10. 磷脂酰丝氨酸受体 Tim-4 对于维持常驻腹腔巨噬细胞的平衡状态至关重要。  |  Wong, K., et al. 2010. Proc Natl Acad Sci U S A. 107: 8712-7. PMID: 20421466
  11. CD300f 磷脂酰丝氨酸受体招募 p85α 介导抑制自身免疫所需的凋亡细胞清除。  |  Tian, L., et al. 2014. Nat Commun. 5: 3146. PMID: 24477292
  12. 候选适配蛋白CED-6可促进秀丽隐杆线虫吞噬凋亡细胞  |  Liu, QA. and Hengartner, MO. 1998. Cell. 93: 961-72. PMID: 9635426

订购信息

产品名称产品编号规格价格数量收藏夹

PSR 抗体 (H-7)

sc-28348
200 µg/ml
$316.00

PSR (H-7): m-IgG Fc BP-HRP 套装

sc-528431
200 µg Ab; 10 µg BP
$354.00

PSR (H-7): m-IgGκ BP-HRP 套装

sc-520806
200 µg Ab, 40 µg BP
$354.00

PSR 抗体 (H-7) AC

sc-28348 AC
500 µg/ml, 25% agarose
$416.00

PSR 抗体 (H-7) HRP

sc-28348 HRP
200 µg/ml
$316.00

PSR 抗体 (H-7) FITC

sc-28348 FITC
200 µg/ml
$330.00

PSR 抗体 (H-7) PE

sc-28348 PE
200 µg/ml
$343.00

PSR 抗体 (H-7) Alexa Fluor® 488

sc-28348 AF488
200 µg/ml
$357.00

PSR 抗体 (H-7) Alexa Fluor® 546

sc-28348 AF546
200 µg/ml
$357.00

PSR 抗体 (H-7) Alexa Fluor® 594

sc-28348 AF594
200 µg/ml
$357.00

PSR 抗体 (H-7) Alexa Fluor® 647

sc-28348 AF647
200 µg/ml
$357.00

PSR 抗体 (H-7) Alexa Fluor® 680

sc-28348 AF680
200 µg/ml
$357.00

PSR 抗体 (H-7) Alexa Fluor® 790

sc-28348 AF790
200 µg/ml
$357.00

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Service 11
Date published: 2017-01-13

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with PSR (H-7): sc-28348?

Asked by: jerojero
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Service 11
Date published: 2017-01-13
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Rated 4 out of 5 by from Very good in western blottingWestern Blotting Dilution 1:1000 Cell lysate: CFBE (human bronchial cell line) Specific signal at the expected molecular weight
Date published: 2023-01-04
Rated 5 out of 5 by from Excellent in Western BlottingDilution 1:1000 Western blotting in CFBE cell lysate Strong and very clear signal
Date published: 2019-12-11
Rated 5 out of 5 by from good antibodyit worked really well at 1:500 in WB with a very low background
Date published: 2018-11-29
Rated 3 out of 5 by from works in WB onlyWorks well on WB (U2OS cell line) but does not work on IF (no signal)
Date published: 2018-02-07
Rated 5 out of 5 by from 功能很出色我在文献上看到了,觉得条带很好看,所以想要试用一下,看看效果,请帮忙发一下,地址浙江大学医学院附属第二医院
Date published: 2017-12-14
Rated 5 out of 5 by from very goodGreat antibody for western blotting, strong band in HeLa whole cell lysates
Date published: 2017-05-10
Rated 5 out of 5 by from Good antibody for Western BlottingWe used this antibody in WB experiment, got expected bands and very strong signal.
Date published: 2017-04-11
Rated 5 out of 5 by from Outstanding !!Great product for IHC applications; also outstanding western
Date published: 2017-01-18
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PSR 抗体 (H-7) is rated 4.7 out of 5 by 14.
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