Prostaglandin Bx (CAS 39306-29-1)
CAS Number:
39306-29-1
Purity:
Mixture of oligomers
Molecular Weight:
1,000-1500
Molecular Formula:
(PGB)n n=3-5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Prostaglandin Bx is a mixture of oligomers of PGB1 (sc-201217) with a molecular weight of 1,000-1,500, that has demonstrated anti-inflammatory and cytoprotective activity. This action is thought to be attributed to inhibition of the 14 kDa sPLA2. This compound also has antioxidant and free radical trapping activity, and has been shown to act as a Ca2+ ionophore.
Prostaglandin Bx (CAS 39306-29-1) References
- Calcium ionophore activity of a prostaglandin B1 derivative (PGBx). | Ohnishi, ST. and Devlin, TM. 1979. Biochem Biophys Res Commun. 89: 240-5. PMID: 113006
- Role of human sperm phospholipase A2 in fertilization: effects of a novel inhibitor of phospholipase A2 activity on membrane perturbations and oocyte penetration. | Fry, MR., et al. 1992. Biol Reprod. 47: 751-9. PMID: 1477202
- Inhibitory effect of prostaglandin oligomeric derivatives on 9,10-dimethyl-1,2-benzanthracene-induced hamster lingual carcinomas. | Hidaka, S., et al. 1992. Cancer Lett. 61: 171-6. PMID: 1730141
- Mechanism(s) of cytoprotective and anti-inflammatory activity of PGB1 oligomers: PGBx has potent anti-phospholipase A2 and anti-oxidant activity. | Franson, RC., et al. 1991. Prostaglandins Leukot Essent Fatty Acids. 43: 63-70. PMID: 1886908
- Protection of rat spinal cord against contusion injury by new prostaglandin derivatives. | Ohnishi, ST., et al. 1989. Arzneimittelforschung. 39: 236-9. PMID: 2730694
- Protection and reactivation of oxidative phosphorylation in mitochondria by a stable free-radical prostaglandin polymer (PGBx). | Polis, BD., et al. 1979. Proc Natl Acad Sci U S A. 76: 1598-602. PMID: 287000
- Prostaglandin derivative PGBx improves neurologic recovery after ischemic spinal injury. | Jacobs, TP., et al. 1987. Pharm Res. 4: 130-2. PMID: 3509135
- Prostaglandin Bx in the prevention of stress ulcers in rats. | Kumashiro, R., et al. 1985. Int Surg. 70: 247-50. PMID: 3835168
- The roles of degranulation and superoxide anion generation in neutrophil aggregation. | Kaplan, HB., et al. 1982. Biochim Biophys Acta. 721: 55-63. PMID: 6289915
- Acute toxicity of prostaglandin Bx in male, albino, ICR mice. | Burkman, AM. 1982. Res Commun Chem Pathol Pharmacol. 37: 97-104. PMID: 7123004
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin Bx, 500 µg | sc-222193 | 500 µg | $31.00 | |||
Prostaglandin Bx, 1 mg | sc-222193A | 1 mg | $58.00 |