Poly-L-histidine (CAS 26062-48-6)
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Poly-L-histidine is a polypeptide that has gained significant attention in the field of biomaterials research due to its pH-sensitive properties. This polymer′s imidazole side chains, which resemble the amino acid histidine, allow it to interact with proton donors and acceptors, making it a prime candidate for developing chemical delivery systems that respond to the acidic environments typically found in certain cellular compartments or pathological sites. In tissue engineering, the thermosensitive behavior of poly-L-histidine has been explored as a means to create scaffolds that undergo conformational changes at body temperature, thereby providing support for cell attachment and growth. Its ability to chelate metal ions also makes it an interesting molecule for creating novel materials with applications in biomineralization and the construction of biosensors. Moreover, researchers utilize poly-L-histidine in the study of protein-protein interactions, as its repeating histidine units can mimic certain aspects of natural recognition processes.
Poly-L-histidine (CAS 26062-48-6) References
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- Poly-L-histidine downregulates fibrinolysis. | Chu, AJ. and Mathews, ST. 2003. Blood Coagul Fibrinolysis. 14: 627-32. PMID: 14517486
- Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new photosensitizing precursors of protoporphyrin IX for photodynamic colon cancer therapy. | Johnson, RP., et al. 2012. Int J Nanomedicine. 7: 2497-512. PMID: 22679363
- Poly(l-histidine) based triblock copolymers: pH induced reassembly of copolymer micelles and mechanism underlying endolysosomal escape for intracellular delivery. | Zhang, X., et al. 2014. Biomacromolecules. 15: 4032-45. PMID: 25308242
- Poly(L-histidine) based copolymers: Effect of the chemically substituted L-histidine on the physio-chemical properties of the micelles and in vivo biodistribution. | Zhang, X., et al. 2016. Colloids Surf B Biointerfaces. 140: 176-184. PMID: 26764099
- pH-responsive nanomicelles of poly(ethylene glycol)-poly(ε-caprolactone)-poly(L-histidine) for targeted drug delivery. | Wang, P., et al. 2020. J Biomater Sci Polym Ed. 31: 277-292. PMID: 31665964
- Preparation and evaluation of poly(l-histidine) based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells. | Jia, N., et al. 2017. Asian J Pharm Sci. 12: 433-441. PMID: 32104356
- Poly-L-histidine coated microfluidic devices for bacterial DNA purification without chaotropic solutions. | Kastania, AS., et al. 2020. Biomed Microdevices. 22: 44. PMID: 32572586
- Dual-Modality Poly-l-histidine Nanoparticles to Deliver Peptide Nucleic Acids and Paclitaxel for In Vivo Cancer Therapy. | Wahane, A., et al. 2021. ACS Appl Mater Interfaces. 13: 45244-45258. PMID: 34524806
- Development of the poly(l-histidine) grafted carbon nanotube as a possible smart drug delivery vehicle. | Haghi, A., et al. 2022. Comput Biol Med. 143: 105336. PMID: 35219189
- Intelligent poly(l-histidine)-based nanovehicles for controlled drug delivery. | Zhang, Y., et al. 2022. J Control Release. 349: 963-982. PMID: 35944751
- Surface functionalization of graphene nanosheet with poly (L-histidine) and its application in drug delivery: covalent vs non-covalent approaches. | Najafi Rad, Z., et al. 2022. Sci Rep. 12: 19046. PMID: 36351935
- Next-generation poly-L-histidine formulations for miRNA mimic delivery. | Kasina, V., et al. 2023. Mol Ther Methods Clin Dev. 29: 271-283. PMID: 37123088
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Poly-L-histidine, 1 mg | sc-296111 | 1 mg | $82.00 | |||
Poly-L-histidine, 10 mg | sc-296111A | 10 mg | $160.00 |