Podophyllotoxin CAS: 518-28-5
MF: C22H22O8
MW: 414.41
A potent inhibitor of microtubule assembly and DNA topoisomerase II.

Podophyllotoxin (CAS 518-28-5)

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同义词: Podophyllic Acid Lactone
应用; A potent inhibitor of microtubule assembly and DNA topoisomerase II
CAS号码: 518-28-5
纯度: ≥98%
分子量: 414.41
分子式: C22H22O8
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
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Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin. It is an antineoplastic glucoside and antitumor agent. Also, podophyllotoxin is a Topo II (DNA topoisomerase II) and tubulin inhibitor.


参考文献

Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross- resistance studies with various microtubule inhibitors and podophyllotoxin analogues: R.S. Gupta; Cancer Res. 43, 505 (1983) Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents: T. Terada, et al.; Chem. Pharmacol. Bull. (Tokyo) 40, 2720 (1992) Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin: D.L. Sackett; Pharmacol. Therap. 59, 163 (1993) Antineoplastic and antiviral activities of podophyllotoxin related lignans: M. Gordaliza, et al.; Arch. Pharmacol. 327, 175 (1994) Er:YAG laser followed by topical podophyllotoxin for hard-to-treat palmoplantar warts.: U. Wollina; Cosmet. Laser Ther. 5, 35 (2003) An evidence-based review of medical and surgical treatments of genital warts.: N. Scheinfeld & DS. Lehman; Dermatol. Online J. 12, 5 (2006)

物理状态 :
Solid
来源于 :
Podophyllum peltatum
溶解度 :
Soluble in 100 % ethanol, chloroform, acetone, water (0.12 mg/ml), and methanol.
保存 :
Store at 4° C
熔点 :
183-184° C (lit.)
沸点 :
~597.9° C at 760 mmHg (Predicted)
密度 :
~1.4 g/cm3 (Predicted)
折射率 :
n20D 1.61 (Predicted)
光学活性 :
α20/D -131°±2°, c = 1 in chloroform
IC50 :
KB : IC50 = 0.5 nM (human); L6: IC50 = 1.7 nM (rat); HT-29: IC50 = 2.9 nM (human); 1A9: IC50 = 3 nM (human); P388: IC50 = 5.9 nM (mouse)
Ki 数据 :
Tubulin: Ki= 2.18 µM (human)
pK值 :
pKa: 13.26 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
LV2500000
默克索引 :
14: 7546
MDL 号码 :
MFCD00075290
EC号码 :
208-250-4
Beilstein 注册 :
99163
SMILES :
COC1=CC(=CC(=C1OC)OC)[[email protected]]2[[email protected]@H]3[[email protected]](COC3=O)[[email protected]](C4=CC5=C(C=C24)OCO5)O

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