Date published: 2025-9-8

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PKD2 抗体 (431.2): sc-100415

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说明书
  • PKD2抗体(431.2)是小鼠单克隆IgG2b κ, 在5篇文献中引用,规格为50 µg/0.5 ml
  • 免疫human物种的重组PKD2
  • 推荐用于 human 来源的PKD2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前,我们还没有完成PKD2 抗体 (431.2)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

PKD2(蛋白激酶D2),也称为PRKD2或HSPC187,是一种广泛表达的蛋白,属于丝氨酸/苏氨酸激酶的蛋白激酶D(PKD)家族。在哺乳动物中,PKD家族有三个成员,即PKC µ、PKD2和PKC ν,它们各自含有一个同源的催化结构域,但在组织表达和亚细胞定位上有所不同。PKD家族成员由G蛋白偶联受体(GPCRs)激活,并已知参与增殖、凋亡、迁移、信号转导和囊泡脱落等生物过程。PKD2在细胞核和细胞质之间穿梭,包含一个PH结构域、一个蛋白激酶结构域和两个佛波酯/DAG型锌指,并作为钙离子非依赖、磷脂依赖的蛋白激酶发挥作用。在CCK-BR激活后,PKD2被酪蛋白激酶I同工型磷酸化,随后在细胞核中累积。PKD2在细胞核中的累积导致Nur77的转录激活和HDAC7的核排斥。这表明PKD2介导了CCK-BR诱导的转录激活。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PKD2 抗体 (431.2) 参考文献:

  1. 人类多囊肾病 2(PKD2)基因突变。  |  Deltas, CC. 2001. Hum Mutat. 18: 13-24. PMID: 11438989
  2. 人类 PKD1-PKD2 复合物的结构。  |  Su, Q., et al. 2018. Science. 361: PMID: 30093605
  3. 高PKD2通过促进上皮-间质转化预测肺腺癌的不良预后  |  Pang, Z., et al. 2019. Sci Rep. 9: 1324. PMID: 30718593
  4. PKD2/polycystin-2 通过与 BECN1 形成复合物诱导自噬。  |  Peña-Oyarzun, D., et al. 2021. Autophagy. 17: 1714-1728. PMID: 32543276
  5. 缺乏PKD2会损害PERK-TBL2-eIF2ɑ-ATF4途径,从而抑制ADPKD中氨基酸的生物合成。  |  Zhou, X., et al. 2021. Biochem Biophys Res Commun. 561: 73-79. PMID: 34015761
  6. Circ-PKD2 通过抑制 miR-646 促进 Atg13 介导的自噬,从而提高口腔鳞状细胞癌对顺铂的敏感性。  |  Gao, L., et al. 2022. Cell Death Dis. 13: 192. PMID: 35220397
  7. PKD1和PKD2 mRNA顺式抑制推动了多囊肾病的进展。  |  Lakhia, R., et al. 2022. Nat Commun. 13: 4765. PMID: 35965273
  8. 通过微型基因检测,确定了 PKD1 和 PKD2 基因中改变 RNA 剪接的 11 个外显子变异。  |  Liu, X., et al. 2023. BMC Genomics. 24: 407. PMID: 37468838
  9. 胚胎Aqp2 +祖细胞中的Pkd2缺陷足以导致严重的多囊肾病。  |  Tsilosani, A., et al. 2024. J Am Soc Nephrol. 35: 398-409. PMID: 38254271
  10. 通过长读测序对常染色体显性多囊肾病中的 PKD1 和 PKD2 进行全面分析  |  Xu, D., et al. 2024. Clin Chem. 70: 841-854. PMID: 38527221

订购信息

产品名称产品编号规格价格数量收藏夹

PKD2 抗体 (431.2)

sc-100415
50 µg/0.5 ml
$333.00

Can sc-100415: PKD2 (431.2) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Dr Ninau Qelp
Thank you for your question. Yes, sc-100415: PKD2 (431.2) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from This has worked well in WBThis has worked well in WB.
Date published: 2015-10-22
Rated 4 out of 5 by from Robust immunoperoxidase cytoplasmic stainingRobust immunoperoxidase cytoplasmic staining in formalin-fixed, paraffin-embedded human tonsil tissue. -SCBT QC
Date published: 2015-01-04
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PKD2 抗体 (431.2) is rated 4.3 out of 5 by 3.
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