Date published: 2025-9-8
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PIPK I γ Antibody (F-11) - Western Blotting - Image 357952
PIPK I γ (F-11): sc-390020. K-562 (A), C6 (B), HeLa (C), Hep G2 (D), A-431 (E) 和 EOC 20 (F) 全细胞裂解液中 PIPK I γ 表达的 Western 印迹分析.
PIPK I γ (F-11): sc-390020. K-562 (A), C6 (B), HeLa (C), Hep G2 (D), A-431 (E) 和 EOC 20 (F) 全细胞裂解液中 PIPK I γ 表达的 Western 印迹分析.

PIPK I γ 抗体 (F-11): sc-390020

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说明书
  • PIPK I γ抗体(F-11)是小鼠单克隆IgG1 (kappa轻链)，规格为200 µg/ml
  • 特异性抗原位于mouse物种的PIPK I γ的C-terminus的氨基酸633-661之间
  • 推荐用于 mouse, rat 和 human 来源的PIPK I γ WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是PIPK I γ Antibody (F-11) for WB applications. 的首选辅助检测试剂，这些试剂现与PIPK I γ Antibody (F-11) 打包提供（请参阅下面的订购信息）。

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    说明书与实验方案
    研究信息

    関連項目

    附加PIPK抗体，包括PIPK I, PIPK I α, PIPK I β, PIPK I γ, PIPK II和PIPK II α

    磷脂酰肌醇-4-磷酸-5-激酶（PIPK）合成磷脂酰肌醇-4,5-二磷酸，该物质可调节包括细胞增殖、存活、膜转运和细胞骨架组织在内的各种过程。PIPK家族分为I型、II型和III型。PIPK家族的每种类型都磷酸化不同的底物，并且它们含有一个激活环，这决定了它们的酶特异性和亚细胞定位。磷脂酰肌醇-4-磷酸-5-激酶I型由三个成员组成，即PIPK I α、β和γ，它们的特点是在5-羟基上磷酸化PI4P。PIPK I α（在小鼠中称为PIPK I β）在脑组织中表达。PIPK I β（在小鼠中称为PIPK I a）也被称为STM7。PIPK I γ通过选择性剪接产生两种变体，在肺、脑和肾脏中表达。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    PIPK I γ 抗体 (F-11) 参考文献:

    1. 两种新型磷脂酰肌醇-4-磷酸5-激酶Igamma剪接变异体在人类细胞中表达，具有独特的细胞靶向性。  |  Schill, NJ. and Anderson, RA. 2009. Biochem J. 422: 473-82. PMID: 19548880
    2. 脑内磷脂酰肌醇-4-磷酸5-激酶和磷脂酰肌醇4,5-二磷酸的合成。  |  Volpicelli-Daley, LA., et al. 2010. J Biol Chem. 285: 28708-14. PMID: 20622009
    3. PIPKIγ 以中心体为靶点，抑制中心粒复制。  |  Xu, Q., et al. 2014. J Cell Sci. 127: 1293-305. PMID: 24434581
    4. Shp1 和 PIPKIγ 之间的交叉对话控制着白细胞的招募。  |  Stadtmann, A., et al. 2015. J Immunol. 195: 1152-61. PMID: 26101325
    5. 磷脂酰肌醇磷酸激酶 PIPKIγ 和磷酸酶 INPP5E 协调纤毛生成的启动。  |  Xu, Q., et al. 2016. Nat Commun. 7: 10777. PMID: 26916822
    6. 癌症中磷脂信号传导的隐藏难题。  |  Thapa, N., et al. 2016. Trends Cancer. 2: 378-390. PMID: 27819060
    7. SUMO化是PIPK1γ驱动的角质细胞迁移和生长所必需的。  |  Ni, W., et al. 2019. FEBS J. 286: 4709-4720. PMID: 31276292
    8. 纤毛病蛋白 HYLS1 通过激活纤毛脂质激酶 PIPKIγ 来协调初级纤毛的生物发生和信号传导。  |  Chen, C., et al. 2021. Sci Adv. 7: PMID: 34162535
    9. 靶向I型和γ型磷脂酰肌醇磷酸激酶可克服结直肠癌对奥沙利铂的耐药性。  |  Yu, M., et al. 2022. Theranostics. 12: 4386-4398. PMID: 35673560
    10. 磷脂酰肌醇和小型热休克蛋白对NRF2的调节。  |  Chen, C., et al. 2024. bioRxiv.. PMID: 37961303

    订购信息

    产品名称产品编号规格价格数量收藏夹

    PIPK I γ 抗体 (F-11)

    sc-390020
    200 µg/ml
    		$316.00

    PIPK I γ (F-11): m-IgG Fc BP-HRP 套装

    sc-540741
    200 µg Ab; 10 µg BP
    		$354.00

    PIPK I γ (F-11): m-IgG1 BP-HRP 套装

    sc-542339
    200 µg Ab; 20 µg BP
    		$354.00

    PIPK I γ (F-11) 中和勝肽

    sc-390020 P
    100 µg/0.5 ml
    		$68.00

    What application is the blocking peptide sc-390020 P appropriate for?

    Asked by: jenniferc
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by from Produced superb immunofluorescence cytoplasmicProduced superb immunofluorescence cytoplasmic staining in methanol-fixed NIH/3T3 cells. -SCBT QC
    Date published: 2015-05-19
    Rated 5 out of 5 by from Clean blot with single strong band at expectedClean blot with single strong band at expected size using EOC 20 whole cell lysate. -SCBT QC
    Date published: 2015-04-14
    Rated 5 out of 5 by from Band detected at expected mw in mouse brainBand detected at expected mw in mouse brain tissue extract. -SCBT QC
    Date published: 2015-01-04
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    PIPK I γ 抗体 (F-11) is rated 5.0 out of 5 by 3.
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