Date published: 2025-9-9

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PIPK I α 抗体 (E-3): sc-376195

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说明书
  • PIPK I α抗体(E-3)是小鼠单克隆IgG3 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于mouse物种的PIPK I α的C-terminus附近的氨基酸481-519之间
  • 推荐用于 mouse, rat 和 human 来源的PIPK I α (designated PIPK I β in mouse) WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前,我们还没有完成PIPK I α 抗体 (E-3)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    関連項目

    磷脂酰肌醇-4-磷酸-5-激酶(PIPK)合成磷脂酰肌醇-4,5-二磷酸,后者调节各种过程,包括细胞增殖、存活、膜转运和细胞骨架组织。PIPK家族分为I型、II型和III型。PIPK家族的每种类型都磷酸化不同的底物,并且它们含有一个决定其酶特异性和亚细胞定位的激活环。磷脂酰肌醇-4-磷酸-5-激酶I型由三个成员组成,即PIPK I α、β和γ,其特点是在5-羟基上磷酸化PI4P。PIPK I α(在小鼠中指定为PIPK I β)在脑组织中表达。PIPK I β(在小鼠中指定为PIPK I α)也被称为STM7。PIPK I γ有两种变体,由肺、脑和肾中的替代剪接表达产生。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    PIPK I α 抗体 (E-3) 参考文献:

    1. 磷脂酰肌醇-4-磷酸 5-激酶是小鼠精子发生过程中不可或缺的物质。  |  Hasegawa, H., et al. 2012. Biol Reprod. 86: 136, 1-12. PMID: 22321832
    2. CLIC1 招募 PIP5K1A/C,诱导细胞与基质粘连,促进肿瘤转移。  |  Peng, JM., et al. 2021. J Clin Invest. 131: PMID: 33079727
    3. β2-微球蛋白维持胶质母细胞瘤干细胞并诱导肿瘤相关巨噬细胞的 M2 样极化  |  Li, D., et al. 2022. Cancer Res. 82: 3321-3334. PMID: 35841593
    4. PIP5K1A 在癌症发展和恶化中的作用。  |  Yin, M. and Wang, Y. 2022. Med Oncol. 39: 151. PMID: 35852640
    5. 基孔肯雅病毒 nsP1 可诱导迁移体的形成。  |  Zhang, N., et al. 2022. J Infect. 85: e158-e161. PMID: 35933040
    6. 通过 miR-942-5p/NFIB 轴抑制 circ-PIP5K1A 克服卵巢癌对顺铂的耐药性  |  Sheng, H. and Wang, X. 2023. Anticancer Drugs. 34: 214-226. PMID: 36730637
    7. 磷脂酰肌醇(4,5)-二磷酸-Rab35 轴调控迁移体的形成。  |  Ding, T., et al. 2023. Cell Res. 33: 617-627. PMID: 37142675
    8. 脂质激酶PIP5K1A通过与核输出蛋白XPO5相互作用调控let-7 microRNA的生物发生。  |  Li, C., et al. 2023. Nucleic Acids Res. 51: 9849-9862. PMID: 37655623
    9. 核磷酸肌酸信号促进乳腺癌中 YAP/TAZ-TEAD 的转录物活性。  |  Jung, O., et al. 2024. EMBO J. 43: 1740-1769. PMID: 38565949
    10. 鲁帕他定通过 PIP5K1A/Akt/CDK2 通路抑制结直肠癌细胞增殖  |  Jiang, L., et al. 2024. Biomed Pharmacother. 176: 116826. PMID: 38838507

    订购信息

    产品名称产品编号规格价格数量收藏夹

    PIPK I α 抗体 (E-3)

    sc-376195
    200 µg/ml
    $316.00

    PIPK I α (E-3) 中和勝肽

    sc-376195 P
    100 µg/0.5 ml
    $68.00

    What application is the blocking peptide sc-376195 P appropriate for?

    Asked by: Professor Griffin
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by from GreatGreat, strong band in WB in mouse PIPK I transfected 293T whole cell lysate. -SCBT QC
    Date published: 2015-06-27
    Rated 5 out of 5 by from Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human tonsil tissue. -SCBT QC
    Date published: 2015-02-21
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    PIPK I α 抗体 (E-3) is rated 5.0 out of 5 by 2.
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