Date published: 2025-9-6
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PI 3-kinase p110δ Antibody (A-8) - Western Blotting - Image 134793
PI 3-kinase p110δ (A-8): sc-55589. C32 (A), NIH/3T3 (B), K-562 (C), Raji (D) 和 Jurkat (E) 全细胞裂解液中 PI 3- 激酶 p110δ 表达的 Western 印迹分析.
PI 3-kinase p110δ (A-8): sc-55589. C32 (A), NIH/3T3 (B), K-562 (C), Raji (D) 和 Jurkat (E) 全细胞裂解液中 PI 3- 激酶 p110δ 表达的 Western 印迹分析.

PI 3-kinase p110δ 抗体 (A-8): sc-55589

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说明书
  • PI 3-kinase p110 delta 抗体 A-8 是小鼠单克隆 IgG1 κ，PI 3-kinase p110δ抗体, 在24篇文献中引用，规格为200 µg/ml
  • 针对氨基酸363-582，在PI 3-kinase p110δ的human起源的N-terminus处进行映射
  • PI 3-kinase p110 delta 抗体 (A-8) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 PI 3-kinase p110δ
  • 抗PI 3-kinase p110 delta抗体（A-8）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取PI 3-kinase p110δ (A-8): sc-55589的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 PI 3-kinase p110δ 抗体 (A-8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与PI 3-kinase p110δ 抗体 (A-8) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

此外 PI 3-kinase 抗体包括 PI 3-kinase C2 α, PI 3-kinase C2 β, PI 3-kinase C2 γ, PI 3-kinase p100, PI 3-kinase p101, PI 3-kinase p110, PI 3-kinase p110 α, PI 3-kinase p110 β, PI 3-kinase p110 δ 和 PI 3-kinase p110 γ

PI 3-kinase p110δ 抗体（A-8）是一种小鼠单克隆 IgG1 kappa 轻链抗体，可通过免疫印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和酶联免疫吸附试验（ELISA）检测小鼠、大鼠和人源的 PI 3-kinase p110 delta 蛋白。磷脂酰肌醇激酶 p110δ (A-8) 抗体有非共轭型和多种共轭型，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 共轭物。磷脂酰肌醇 3-激酶（PI 3-激酶）通路在细胞的生长、增殖和存活等功能中起着至关重要的作用，其中 PI 3- 激酶 p110δ 在免疫反应中尤为重要。PI 3 激酶 p110δ 主要在白细胞中表达，PI 3 激酶 p110δ 在白细胞中调节免疫细胞活化和分化所必需的各种信号通路。PI 3 激酶 p110δ 自身磷酸化和调节脂质激酶活性的能力对于维持正常的免疫功能至关重要，因为调节失调会导致免疫紊乱，并与包括癌症和自身免疫性疾病在内的多种疾病有关。了解 PI 3 激酶 p110δ 的相互作用和功能对于开发能有效调节免疫反应的靶向疗法至关重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PI 3-kinase p110δ 抗体 (A-8) 参考文献:

  1. 磷脂酰肌醇 3-激酶：110 kd 催化亚基的结构和表达。  |  Hiles, ID., et al. 1992. Cell. 70: 419-29. PMID: 1322797
  2. 与受体酪氨酸激酶, middle-T/pp60c-src 复合物和 PI3 激酶缔合作用的两种 85 kd 蛋白的特征。  |  Otsu, M., et al. 1991. Cell. 65: 91-104. PMID: 1707345
  3. 利用表达/克隆受体酪氨酸激酶靶蛋白的新方法克隆 PI3 激酶缔合作用 p85。  |  Skolnik, EY., et al. 1991. Cell. 65: 83-90. PMID: 1849461
  4. PI3K p110delta 在小鼠和人类的初级和次级免疫反应过程中调节 T 细胞细胞因子的产物。  |  Soond, DR., et al. 2010. Blood. 115: 2203-13. PMID: 20081091
  5. 白细胞信号转导和功能中的磷酸肌醇 3- 激酶δ（PI3KΔ）。  |  Fung-Leung, WP. 2011. Cell Signal. 23: 603-8. PMID: 20940048
  6. p37Δ 是 PI3K p110Δ 的一种新异构体，可增加细胞增殖并在肿瘤中过度表达。  |  Fransson, S., et al. 2012. Oncogene. 31: 3277-86. PMID: 22020336
  7. 精神分裂症中的神经调节素1-ErbB4-PI3K信号传导和磷脂酰肌醇3-激酶-p110δ抑制作为潜在的治疗策略。  |  Law, AJ., et al. 2012. Proc Natl Acad Sci U S A. 109: 12165-70. PMID: 22689948
  8. PIK3CD突变引起的磷脂酰肌醇3-激酶δ综合征：表型的扩展。  |  Zhao, P., et al. 2024. Pediatr Rheumatol Online J. 22: 24. PMID: 38287413
  9. 磷脂酰肌醇-4,5-二磷酸3-激酶δ异构体在肝细胞增殖中的新作用。  |  Martucci, NJ., et al. 2024. Am J Pathol. 194: 1511-1527. PMID: 38705383
  10. 克隆 G 蛋白激活的人类磷酸肌醇-3 激酶并确定其特性。  |  Stoyanov, B., et al. 1995. Science. 269: 690-3. PMID: 7624799
  11. 克隆一种新的, 普遍表达的人类磷脂酰肌醇 3- 激酶，并确定其在 p85 上的结合位点。  |  Hu, P., et al. 1993. Mol Cell Biol. 13: 7677-88. PMID: 8246984
  12. 白细胞中的新型磷酸肌醇 3- 激酶 P110delta  |  Vanhaesebroeck, B., et al. 1997. Proc Natl Acad Sci U S A. 94: 4330-5. PMID: 9113989

订购信息

产品名称产品编号规格价格数量收藏夹

PI 3-kinase p110δ 抗体 (A-8)

sc-55589
200 µg/ml
$316.00

PI 3-kinase p110δ (A-8): m-IgG Fc BP-HRP 套装

sc-526870
200 µg Ab; 10 µg BP
$354.00

PI 3-kinase p110δ (A-8): m-IgG1 BP-HRP 套装

sc-532243
200 µg Ab; 20 µg BP
$354.00

PI 3-kinase p110δ 抗体 (A-8) AC

sc-55589 AC
500 µg/ml, 25% agarose
$416.00

PI 3-kinase p110δ 抗体 (A-8) HRP

sc-55589 HRP
200 µg/ml
$316.00

PI 3-kinase p110δ 抗体 (A-8) FITC

sc-55589 FITC
200 µg/ml
$330.00

PI 3-kinase p110δ 抗体 (A-8) PE

sc-55589 PE
200 µg/ml
$343.00

PI 3-kinase p110δ 抗体 (A-8) Alexa Fluor® 488

sc-55589 AF488
200 µg/ml
$357.00

PI 3-kinase p110δ 抗体 (A-8) Alexa Fluor® 546

sc-55589 AF546
200 µg/ml
$357.00

PI 3-kinase p110δ 抗体 (A-8) Alexa Fluor® 594

sc-55589 AF594
200 µg/ml
$357.00

PI 3-kinase p110δ 抗体 (A-8) Alexa Fluor® 647

sc-55589 AF647
200 µg/ml
$357.00

PI 3-kinase p110δ 抗体 (A-8) Alexa Fluor® 680

sc-55589 AF680
200 µg/ml
$357.00

PI 3-kinase p110δ 抗体 (A-8) Alexa Fluor® 790

sc-55589 AF790
200 µg/ml
$357.00

Hello, As you mentioned: (Contactez-nous pour recevoir un échantillon GRATUIT de 10 µg sample de PI 3-kinase p110δ (A-8): sc-55589). I wanted to ask you if it is possible to have it free, then later buy it. Thank you

Asked by: hose
Thank you for your question. If you have an interest in testing a free 10 µg sample of PI 3-kinase p110 (A-8): sc-55589 please contact our Technical Service by phone or email or by Live Chat.
Answered by: SCBT Heidelberg Support
Date published: 2018-11-27

I will be performing some IF and IHC on my mouse samples. Do you have any suggestions for this procedure?

Asked by: Cweed
We recommend using a directly conjugated primary antibody. This product, sc-55589, is available directly conjugated to AF488, AF647, and FITC.
Answered by: Technical Support 12
Date published: 2017-01-12

What is the best secondary reagent to use with sc-55589?

Asked by: Cweed
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 12
Date published: 2017-01-12
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Rated 5 out of 5 by from Produced publishable data on m,r and hThis PI 3-kinase p110 monoclonal was featured in a dozen of publications for the use of WB, IHC, ChIP on mouse, rat and human samples
Date published: 2017-01-30
Rated 5 out of 5 by from Superb product !!Great product for multiple applications including IF, WB and IHC staining
Date published: 2017-01-30
Rated 5 out of 5 by from Good antibodyI used the antibody to detect PI3K, high sensitive. The product is very good.
Date published: 2016-10-27
Rated 5 out of 5 by from Good specificity in WB in C32Good specificity in WB in C32, NIH/3T3, K-562, Raji and Jurkat whole cell lysates. -SCBT QC
Date published: 2015-04-29
Rated 5 out of 5 by from Worked well in ChIP in human 293T cellsWorked well in ChIP in human 293T cells. -SCBT Publication Review
Date published: 2015-04-29
Rated 5 out of 5 by from Exceptional immunoperoxidase cytoplasmicExceptional immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human brain tissue. -SCBT QC
Date published: 2015-02-21
Rated 5 out of 5 by from Single strong band in WB in KSingle strong band in WB in K-562 whole cell lysates. -SCBT QC
Date published: 2015-01-23
Rated 5 out of 5 by from Single strong band in WB in KSingle strong band in WB in K-562 whole cell lysates. -SCBT QC
Date published: 2015-01-23
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PI 3-kinase p110δ 抗体 (A-8) is rated 5.0 out of 5 by 8.
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