PI 3-kinase C2 beta Antibody (22): sc-136031

PI 3-kinase C2β Antibody (22) is a mouse monoclonal IgG1 antibody that detects PI 3-kinase C2β in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). PI 3-kinase C2β, also known as p110-β, is a crucial 1,070 amino acid protein that plays a significant role in cellular signaling pathways, particularly those that regulate cell growth and survival in response to various mitogenic stimuli. Anti-PI 3-kinase C2β antibody (22) recognizes a protein primarily located in the cytoplasm and involved in the modulation of integrin adhesion bonds, specifically α2B (ITGA2B) and β3 (ITGB3), which are vital for platelet activation under shear stress conditions. The interaction between PI 3-kinase C2β and these integrins is essential for maintaining proper hemostasis and responding to vascular injury, highlighting PI 3-kinase C2β′s importance in both normal physiology and pathological conditions such as thrombosis. With participation in critical signaling pathways, PI 3-kinase C2β serves as a valuable target for research into cell growth regulation and related diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PI 3-kinase C2 beta Antibody (22) References:

1. Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.  |  Foukas, LC., et al. 2002. J Biol Chem. 277: 37124-30. PMID: 12145276
2. Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.  |  Czupalla, C., et al. 2003. J Biol Chem. 278: 11536-45. PMID: 12502714
3. Targeted RNA interference of phosphatidylinositol 3-kinase p110-beta induces apoptosis and proliferation arrest in endometrial carcinoma cells.  |  An, HJ., et al. 2007. J Pathol. 212: 161-9. PMID: 17427168
4. Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets.  |  Schoenwaelder, SM., et al. 2007. J Biol Chem. 282: 28648-28658. PMID: 17673465
5. Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells.  |  Tsukamoto, K., et al. 2008. J Immunol. 180: 2054-61. PMID: 18250410
6. Evidence for a role for the p110-alpha isoform of PI3K in skeletal function.  |  Grey, A., et al. 2010. Biochem Biophys Res Commun. 391: 564-9. PMID: 19931507
7. Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.  |  Schoenwaelder, SM., et al. 2010. J Biol Chem. 285: 2886-96. PMID: 19940148
8. Targeting the phosphoinositide 3-kinase p110-α isoform impairs cell proliferation, survival, and tumor growth in small cell lung cancer.  |  Wojtalla, A., et al. 2013. Clin Cancer Res. 19: 96-105. PMID: 23172887
9. G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN.  |  Zuo, B., et al. 2022. Mol Biol Rep. 49: 2629-2639. PMID: 34997428
10. Visible light accelerates skin wound healing and alleviates scar formation in mice by adjusting STAT3 signaling.  |  Deng, F., et al. 2024. Commun Biol. 7: 1266. PMID: 39367154

The preferred PI 3-kinase C2β antibody is PI 3-kinase C2β Antibody (16L9): sc-100407.