PGF2α (Prostaglandin F2α) CAS: 38562-01-5
MF: C20H33O5·C4H12NO3
MW: 475.6
Binds to PGF2Rα, shown to stimulate COX2 expression, and regulate adrenal endocrine function.

PGF2α (Prostaglandin F2α) (CAS 38562-01-5)

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备用名: Prostaglandin F tromethamine salt;Dinoprost Tromethamine
应用; PGF2α (Prostaglandin F2α) is binds to PGF2Rα, shown to stimulate COX2 expression, and regulate adrenal endocrine function
CAS号码: 38562-01-5
纯度: ≥99%
分子量: 475.6
分子式: C20H33O5·C4H12NO3
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

PGF (Prostaglandin F) is a major uterine luteolytic prostaglandin, that is an endogenous agonist of PGF2Rα (FP receptor; KD=1.0 nM). This product has been shown to inhibit differentiation of mouse 3T3-L1 preadipocytes, promote neutrophil chemotaxis via the chemokine CXCL1 in endometrial adenocarcinoma cells, stimulate COX2 mRNA expression and thereby PGF synthesis through NF-κB activation via reactive oxygen species (ROS) in the corpus luteum of pseudopregnant rats, and regulate adrenal endocrine function. PGF is synthesized from PGE2 (sc-201225), both of which are synthesized from the same precursor, PGH2 (sc-201266). The diverse activity displayed by PGF, other prostaglandins, and analogous molecules, makes this product an extremely useful research tool.


参考文献

1. Vincent, D.L., et al. 1986. Prostaglandins. 31: 715-733. PMID: 3460114
2. Abramovitz, M., et al. 1994. J. Biol. Chem. 269: 2632-2636. PMID: 8300593
3. Miller, C.W., et al. 1996. Endocrinology. 137: 5641-5650. PMID: 8940395
4. Wallace, A.E., et al. 2009. Cancer Res. 69: 5726-5733. PMID: 19549892
5. Lambert-Langlais, S., et al. 2009. PLoS ONE. 4: e7309. PMID: 19809495
6. Yu, Y., et al. 2009. Proc. Natl. Acad. Sci. U.S.A. 106: 7985-7990. PMID: 19416858
7. Taniguchi, K., et al. 2010. Reproduction. PMID: 20826536

物理状态 :
Solid
溶解度 :
Soluble in water (1 mg/ml), ethanol (~50 mg/ml), PBS (25 mg/ml), DMSO (~50 mg/ml), DMF (~50 mg/ml), and methanol.
保存 :
Store at -20° C
IC50 :
High-affinity choline transporter: IC50 = 2.77 µM (human)
pK值 :
pKa: 4.76
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
UK8025000
PubChem CID :
5282415
默克索引 :
14: 7878
MDL 号码 :
MFCD00077863
EC号码 :
254-002-3
Beilstein 注册 :
4087514
SMILES :
CCCCC[[email protected]@H](/C=C/[[email protected]]1[[email protected]@H](C[[email protected]@H]([[email protected]@H]1C/C=C\\CCCC(=O)O)O)O)O.C(C(CO)(CO)N)O

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引用1 - 33

PMID: # 25173977  Jin, D. et al. 2014. Nature cell biology. 16: 841-51.

PMID: # 4677341  Douglas, RH. et al. 1972. Prostaglandins. 2: 265-268.

PMID: # 5723367  Karim, SM. et al. 1968. Br Med J. 4: 621-623.

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