Molecular structure of Pentafluorobenzyl chloroformate, CAS Number: 53526-74-2
Pentafluorobenzyl chloroformate (CAS 53526-74-2)
CAS Number:
53526-74-2
Molecular Weight:
260.55
Molecular Formula:
C8H2ClF5O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Pentafluorobenzyl chloroformate (PFB-Cl) stands as a versatile reagent extensively employed in organic synthesis, particularly for the creation of peptides and various compounds. This compound serves as a pivotal starting material in the synthesis of peptides and other compounds, finding diverse applications within the field. In laboratory applications, Pentafluorobenzyl chloroformate is widely utilized for synthesizing peptides and other compounds. The process of synthesizing peptides and compounds involving Pentafluorobenzyl chloroformate relies on the formation of a covalent bond between the target molecule and the pentafluorobenzyl group. This reaction proceeds through a nucleophilic substitution, yielding Pentafluorobenzyl chloroformate and sodium bromide as byproducts. Typically, this reaction takes place in an aqueous solution at a temperature range of 25-30°C.
Pentafluorobenzyl chloroformate (CAS 53526-74-2) References
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- (S)-(-)-N-(pentafluorobenzylcarbamoyl)prolyl chloride: a chiral derivatisation reagent designed for gas chromatography/negative ion chemical ionisation mass spectrometry of amino compounds. | Leis, HJ. and Windischhofer, W. 2012. Rapid Commun Mass Spectrom. 26: 592-8. PMID: 22328211
- Derivatization reactions for use with the electron-capture detector. | Poole, CF. 2013. J Chromatogr A. 1296: 15-24. PMID: 23433885
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- Determination of atmospheric amines by on-fiber derivatization solid-phase microextraction with 2,3,4,5,6-pentafluorobenzyl chloroformate and 9-fluorenylmethoxycarbonyl chloride. | Parshintsev, J., et al. 2015. J Chromatogr A. 1376: 46-52. PMID: 25542706
- Chloroformate derivatization for tracing the fate of Amino acids in cells and tissues by multiple stable isotope resolved metabolomics (mSIRM). | Yang, Y., et al. 2017. Anal Chim Acta. 976: 63-73. PMID: 28576319
- Derivatization chemistries for the determination of inorganic anions and structurally related compounds by gas chromatography - A review. | Pagliano, E., et al. 2018. Anal Chim Acta. 1025: 12-40. PMID: 29801600
- Sample preparation and instrumental methods for illicit drugs in environmental and biological samples: A review. | Chen, X., et al. 2021. J Chromatogr A. 1640: 461961. PMID: 33582515
- Possibilities and limitations of tracing industrial effluents in the sea by means of capillary chromatography. | Josefsson, B. 1983. J Chromatogr. 279: 119-23. PMID: 6672029
- Analysis of amino acids in biological fluids by pentafluorobenzyl chloroformate derivatization and detection by electron capture negative ionization mass spectrometry. | Simpson, JT., et al. 1996. Anal Biochem. 233: 58-66. PMID: 8789147
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pentafluorobenzyl chloroformate, 500 mg | sc-263980 | 500 mg | $94.00 | |||
Pentafluorobenzyl chloroformate, 1 g | sc-263980A | 1 g | $173.00 |