PD 166866 CAS: 192705-79-6
MF: C20H24N6O3
MW: 396.44
An inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for bFGF.

PD 166866 (CAS 192705-79-6)

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应用; PD 166866 is an inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for bFGF
CAS号码: 192705-79-6
纯度: 98%
分子量: 396.44
分子式: C20H24N6O3
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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PD 166866 is a potent inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for FGF-2 (bFGF). It has no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases, or MEK, PKC, or CDK4. PD 166866 is an inhibitor of Flg (FGFR1).


参考文献

Zhu, X., et al.: Science, 251, 90 (1991), Davies, D.E., et al.: Biochem. Pharmacol., 51, 1101 (1996), Panek, R.L., et al.: J. Pharmacol. Exp. Ther., 286, 569 (1998), Iacoangeli, A., et al.: Biochimie, 82, 35 (2000),

物理状态 :
Solid
溶解度 :
Soluble in DMSO (≥10 mg/ml).
保存 :
Store at -20° C
熔点 :
291-293°C (lit.)
密度 :
1.28 g/cm3 (Predicted)
折射率 :
n20D 1.64 (Predicted)
IC50 :
Fibroblast growth factor receptor 1: IC50 = 48 nM (human); c-Src : IC50 = > 50 µM; Cyclin-dependent kinase 4: IC50 = >40 µM (human); Fibroblast growth factor receptor 3: IC50 = 60 nM (human); HUVEC50 : IC50 = 100 nM (human); Fibroblast growth factor receptor 2: IC50 = 60 nM (human); C6 : IC50 = >25 µM (rat)
pK值 :
pKa: 10.15, pKb: 2.95
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
1
PubChem CID :
MDL 号码 :
MFCD12922514
SMILES :
CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC

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