Molecular structure of Paxilline, CAS Number: 57186-25-1
Paxilline (CAS 57186-25-1)
See product citations (14)
Application:
Paxilline is a selective and reversible calcium-activated potassium channel blocker
CAS Number:
57186-25-1
Purity:
≥95%
Molecular Weight:
435.55
Molecular Formula:
C27H33NO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Paxilline is an indole alkaloid isolated from Penicillium paxilli. Paxilline may act to selectively and reversibly block the high conductance Ca2+-activated K+ channel. In neutrophils, Paxilline blockage of Maxi-K channels decreased the alkalinization of phagocytic vacuoles and inhibited the microbicidal process. When paxilline was applied to the smooth muscle of the rat vas deferens at more positive potentials than -40 mV up to 15 mV, significant depolarization of the smooth muscle contractions was observed. Paxilline is an inhibitor of MaxiKalpha, IP3R and SERCA.
Paxilline (CAS 57186-25-1) References
- The mycotoxin paxilline inhibits the cerebellar inositol 1,4, 5-trisphosphate receptor. | Longland, CL., et al. 2000. Eur J Pharmacol. 408: 219-25. PMID: 11090637
- The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels. | Femling, JK., et al. 2006. J Gen Physiol. 127: 659-72. PMID: 16702353
- Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Evidence for a direct association with an inactivating, voltage-dependent, potassium channel. | Vázquez, J., et al. 1990. J Biol Chem. 265: 15564-71. PMID: 1697593
- [Effect of paxilline on Ca(2+)-dependent K+ current in smooth muscle cells isolated from rat vas deferens]. | Kryshtal', DO., et al. 2007. Fiziol Zh (1994). 53: 67-74. PMID: 18080495
- Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism. | Zhou, Y. and Lingle, CJ. 2014. J Gen Physiol. 144: 415-40. PMID: 25348413
- Immunochemical Analysis of Paxilline and Ergot Alkaloid Mycotoxins in Grass Seeds and Plants. | Bauer, JI., et al. 2018. J Agric Food Chem. 66: 315-322. PMID: 29237259
- Paxilline Prevents the Onset of Myotonic Stiffness in Pharmacologically Induced Myotonia: A Preclinical Investigation. | Hoppe, K., et al. 2020. Front Physiol. 11: 533946. PMID: 33329012
- Flavonoid quercetin abolish paxilline inhibition of the mitochondrial BKCa channel. | Kampa, RP., et al. 2022. Mitochondrion. 65: 23-32. PMID: 35504559
- A new tremorgenic metabolite from Penicillium paxilli. | Cole, RJ., et al. 1974. Can J Microbiol. 20: 1159-62. PMID: 4425383
- Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. | Knaus, HG., et al. 1994. Biochemistry. 33: 5819-28. PMID: 7514038
- Modulation of the Ca(2+)-dependent K+ channel, hslo, by the substituted diphenylurea NS 1608, paxilline and internal Ca2+. | Strøbaek, D., et al. 1996. Neuropharmacology. 35: 903-14. PMID: 8938721
- Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. | Sanchez, M. and McManus, OB. 1996. Neuropharmacology. 35: 963-8. PMID: 8938726
- Paxilline-negative mutants of Penicillium paxilli generated by heterologous and homologous plasmid integration. | Young, C., et al. 1998. Curr Genet. 33: 368-77. PMID: 9618588
Inhibitor of:
IP3R, MaxiK, and SERCA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Paxilline, 5 mg | sc-3588 | 5 mg | $258.00 | |||
Paxilline, 25 mg | sc-3588A | 25 mg | $942.00 |