p57 Kip2 Antibody (H-12): sc-515909
- p57 Kip2 Antibody (H-12) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 318-337 at the C-terminus of p57 Kip2 of mouse origin
- recommended for detection of p57 Kip2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for p57 Kip2 Antibody (H-12) for WB applications. This reagent is now offered in a bundle with p57 Kip2 Antibody (H-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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p57 Kip2 Antibody (H-12) is a mouse monoclonal IgM antibody that detects p57 Kip2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p57 Kip2, also known as Kip2, is a crucial member of the p21 Waf1/Cip1/p27 family of cyclin-dependent kinase inhibitors, playing a significant role in regulating cell cycle progression by inhibiting several G1 cyclin/Cdk complexes. This inhibition is vital for maintaining proper cell cycle control, particularly in response to cellular stress or DNA damage, as p57 Kip2 prevents premature progression into the S phase, thereby allowing time for DNA repair mechanisms to function effectively. Unlike p21 Waf1/Cip1 and p27, p57 Kip2 operates independently of p53 regulation, which highlights p57 Kip2′s unique role in cell cycle regulation and potential implications in tumorigenesis when dysregulated. Anti-p57 Kip2 antibody (H-12) is an essential tool for researchers studying cell cycle dynamics, cancer biology, and the intricate signaling pathways that govern cellular responses to stress.
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p57 Kip2 Antibody (H-12) References:
- Distant cis-elements regulate imprinted expression of the mouse p57(Kip2) (Cdkn1c) gene: implications for the human disorder, Beckwith--Wiedemann syndrome. | John, RM., et al. 2001. Hum Mol Genet. 10: 1601-9. PMID: 11468278
- Expression of cell cycle regulators p57(KIP2), cyclin D1, and cyclin E in epithelial ovarian tumors and survival. | Rosenberg, E., et al. 2001. Hum Pathol. 32: 808-13. PMID: 11521224
- Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells. | Yaswen, P. and Stampfer, MR. 2002. Int J Biochem Cell Biol. 34: 1382-94. PMID: 12200033
- p57KIP2 immunohistochemistry in early molar pregnancies: emphasis on its complementary role in the differential diagnosis of hydropic abortuses. | Merchant, SH., et al. 2005. Hum Pathol. 36: 180-6. PMID: 15754295
- Multiplex short tandem repeat DNA analysis confirms the accuracy of p57(KIP2) immunostaining in the diagnosis of complete hydatidiform mole. | Popiolek, DA., et al. 2006. Hum Pathol. 37: 1426-34. PMID: 16949913
- Down-regulation of p57Kip2 induces prostate cancer in the mouse. | Jin, RJ., et al. 2008. Cancer Res. 68: 3601-8. PMID: 18483241
- [Expression of p57(kip2) gene in placenta tissue of patients with pre-eclampsia]. | He, GL., et al. 2015. Sichuan Da Xue Xue Bao Yi Xue Ban. 46: 123-8. PMID: 25807810
- Role of the Atg9a gene in intrauterine growth and survival of fetal mice. | Kojima, T., et al. 2015. Reprod Biol. 15: 131-8. PMID: 26370455
- The small molecule kobusone can stimulate islet β-cell replication in vivo. | Choi, JW., et al. 2021. J Int Med Res. 49: 3000605211032849. PMID: 34320857
- Role of p57KIP2 in Stem and Progenitor Leydig Cells of Mouse Testes. | Park, SH., et al. 2024. World J Mens Health.. PMID: 38772531
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p57 Kip2 Antibody (H-12) | sc-515909 | 200 µg/ml | $322.00 | |||
p57 Kip2 Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-552192 | 200 µg Ab; 40 µg BP | $361.00 |