p130 Antibody (DCS-215): sc-53641

p130 Antibody (DCS-215) is a mouse monoclonal IgG1 antibody that detects p130 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p130, a member of the retinoblastoma protein family, plays a crucial role in regulating the cell cycle and maintaining cellular quiescence. The unique structural features of p130, particularly the Loop region, are essential for function, as these are involved in the phosphorylation process that occurs during the G0 and early G1 phases of the cell cycle. This phosphorylation is critical for the transition from a quiescent state to active cell proliferation, as phosphorylation modulates p130′s interaction with E2F transcription factors, thereby influencing gene expression related to cell cycle progression. p130′s ability to be phosphorylated on specific serine and threonine residues under conditions of serum deprivation or density arrest highlights p130′s importance in cellular responses to environmental cues. Anti-p130 antibody (DCS-215) enables researchers to gain valuable insights into the regulatory mechanisms of cell proliferation and p130′s role in various physiological and pathological processes.

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p130 Antibody (DCS-215) References:

1. SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells.  |  Bhattacharya, S., et al. 2003. Oncogene. 22: 2443-51. PMID: 12717421
2. Silencing human Rb2/p130 with shRNA.  |  Leucci, E., et al. 2007. Cell Oncol. 29: 265-8. PMID: 17452779
3. Genomic landscape of retinoblastoma in Rb-/- p130-/- mice resembles human retinoblastoma.  |  Kooi, IE., et al. 2017. Genes Chromosomes Cancer. 56: 231-242. PMID: 27750399
4. The polarity protein Angiomotin p130 controls dendritic spine maturation.  |  Wigerius, M., et al. 2018. J Cell Biol. 217: 715-730. PMID: 29317530
5. Stable overexpression of p130/E2F4 affects the multipotential abilities of bone-marrow-derived mesenchymal stem cells.  |  Zhang, X., et al. 2018. J Cell Physiol. 233: 9739-9749. PMID: 29987913
6. RBL2/p130: a direct AKT substrate and mediator of AKT inhibition-induced apoptosis.  |  Ventura, E., et al. 2018. Oncoscience. 5: 278-280. PMID: 30652113
7. Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer.  |  Yang, J., et al. 2019. Cell Death Dis. 10: 179. PMID: 30792381
8. CLIC1 knockout inhibits invasion and migration of gastric cancer by upregulating AMOT-p130 expression.  |  Qiu, Y., et al. 2021. Clin Transl Oncol. 23: 514-525. PMID: 32656583
9. p130 And pRb in the Maintenance of Transient Quiescence of Mesenchymal Stem Cells.  |  Popov, B., et al. 2020. Stem Cells Int. 2020: 8883436. PMID: 33014072
10. Activation of Wnt/β‑Catenin‑p130/E2F4 promotes the differentiation of bone marrow‑derived mesenchymal stem cells into type II alveolar epithelial cells through cell cycle arrest.  |  Zhang, X., et al. 2023. Exp Ther Med. 26: 330. PMID: 37346406

The preferred p130 antibody is p130 Antibody (A-10): sc-374521.