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p120 Antibody (6H11) - Western Blotting - Image 354731
p120 抗体 (6H11): sc-23873. MDCK (A), NRK (B), PC-12 (C), EOC 20 (D) 和 AMJ2-C8 (E) 全细胞裂解液中 p120 表达的 Western 印迹分析.
p120 抗体 (6H11): sc-23873. MDCK (A), NRK (B), PC-12 (C), EOC 20 (D) 和 AMJ2-C8 (E) 全细胞裂解液中 p120 表达的 Western 印迹分析.

p120 抗体 (6H11): sc-23873

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说明书
  • p120 抗体 6H11 是小鼠单克隆 IgG1 κ，p120抗体, 在24篇文献中引用，规格为200 µg/ml
  • 与mouse的8-349氨基酸残基的p120
  • p120 抗体 (6H11) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat, human, canine 和avian 来源的 p120
  • 抗p120抗体（6H11）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是p120 Antibody (6H11) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与p120 Antibody (6H11) 打包提供（请参阅下面的订购信息）。
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研究信息

関連項目

p120抗体（6H11）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学检测小鼠、大鼠、人类、犬和鸟类来源的p120蛋白。抗p120抗体（6H11）有非结合型和多种 结合形式，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。p120蛋白（也称为CTNND1）通过与E-钙黏蛋白（维持上皮完整性的关键成分）的细胞质尾部相互作用，在细胞黏附中发挥关键作用。这种相互作用对于形成粘附连接至关重要，而粘附连接对于组织结构和细胞通讯必不可少。此外，p120调节E-钙黏蛋白在细胞膜上的稳定性和定位，从而影响控制细胞增殖和分化的细胞信号通路。p120调节E-钙黏蛋白水平的能力凸显其在癌症生物学中的重要性， 因为钙粘蛋白介导的粘附改变会导致肿瘤细胞侵袭性和转移性增加。p120（6H11）单克隆抗体使研究人员能够深入了解细胞粘附的机理以及对癌症进展和治疗的潜在影响。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p120 抗体 (6H11) 参考文献:

  1. P120-catenin亚家族的发展功能。  |  McCrea, PD. and Park, JI. 2007. Biochim Biophys Acta. 1773: 17-33. PMID: 16942809
  2. 在细胞核内外起舞：p120(ctn)和转录因子Kaiso。  |  Daniel, JM. 2007. Biochim Biophys Acta. 1773: 59-68. PMID: 17050009
  3. 癌症中的p120-catenin--干预机制、模型和机会。  |  Schackmann, RC., et al. 2013. J Cell Sci. 126: 3515-25. PMID: 23950111
  4. p120调节慢性鼻-鼻窦炎鼻上皮细胞中的E-钙黏蛋白表达。  |  Li, XL., et al. 2022. Rhinology. 60: 270-281. PMID: 35934314
  5. 筋膜成纤维细胞中p120的治疗性沉默可改善组织修复。  |  Rajendran, V., et al. 2023. J Invest Dermatol. 143: 854-863.e4. PMID: 36442618
  6. p120-Catenin抑制巨噬细胞中NLRP3炎症小体的激活。  |  Kanmani, P., et al. 2023. Am J Physiol Lung Cell Mol Physiol. 324: L596-L608. PMID: 36880663
  7. p120-catenin通过稳定TBK1-IRF3复合物促进先天抗病毒免疫。  |  Wu, H., et al. 2023. Mol Immunol. 157: 8-17. PMID: 36958140
  8. PRMT-1和p120-Catenin是导致NSCLC产生奥希替尼耐药性的EMT介质  |  Racherla, KS., et al. 2023. Cancers (Basel). 15: PMID: 37444572
  9. 化学蛋白质组学策略发现p120-连接蛋白的谷胱甘肽化调节E-钙粘蛋白降解和细胞迁移。  |  Kukulage, DSK., et al. 2023. Cell Chem Biol. 30: 1542-1556.e9. PMID: 37714153
  10. 根据细胞表型，钙粘蛋白17与结蛋白1和p120-连接蛋白的复合物可调节结肠直肠癌的迁移和侵袭。  |  Bartolomé, RA., et al. 2024. J Exp Clin Cancer Res. 43: 31. PMID: 38263178

订购信息

产品名称产品编号规格价格数量收藏夹

p120 抗体 (6H11)

sc-23873
200 µg/ml
$322.00

p120 (6H11): m-IgG Fc BP-HRP 套装

sc-528377
200 µg Ab; 10 µg BP
$361.00

p120 (6H11): m-IgGκ BP-HRP 套装

sc-520739
200 µg Ab, 40 µg BP
$361.00

p120 (6H11): m-IgG1 BP-HRP 套装

sc-542904
200 µg Ab; 20 µg BP
$361.00

p120 抗体 (6H11) AC

sc-23873 AC
500 µg/ml, 25% agarose
$424.00

p120 抗体 (6H11) HRP

sc-23873 HRP
200 µg/ml
$322.00

p120 抗体 (6H11) FITC

sc-23873 FITC
200 µg/ml
$336.00

p120 抗体 (6H11) PE

sc-23873 PE
200 µg/ml
$349.00

p120 抗体 (6H11) Alexa Fluor® 488

sc-23873 AF488
200 µg/ml
$364.00

p120 抗体 (6H11) Alexa Fluor® 546

sc-23873 AF546
200 µg/ml
$364.00

p120 抗体 (6H11) Alexa Fluor® 594

sc-23873 AF594
200 µg/ml
$364.00

p120 抗体 (6H11) Alexa Fluor® 647

sc-23873 AF647
200 µg/ml
$364.00

p120 抗体 (6H11) Alexa Fluor® 680

sc-23873 AF680
200 µg/ml
$364.00

p120 抗体 (6H11) Alexa Fluor® 790

sc-23873 AF790
200 µg/ml
$364.00

Can p120 (6H11): sc-23873 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: AbPolly
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, p120 (6H11): sc-23873 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by wdhalan from Good for WBThis antibody works very well for WB, the dilution ratio is 1:500.
Date published: 2018-03-16
Rated 5 out of 5 by twinsmc from specific/sharp bands detectedThis antibody was tested on human aortic endothelial cells post various treatments. It gives specific band with no background.
Date published: 2017-09-14
Rated 5 out of 5 by SWYC from p120 reviewI used the p120 (6H11) antibody for western blotting at a 1:500 dilution and got a good signal when I was doing an IP and checking for the signal in total lysate.
Date published: 2017-08-25
Rated 5 out of 5 by mazi08 from strong band at 120kdaStrong, reliable and specific, a great antibody for all your p120 detection needs,with specific band at 120kda.
Date published: 2017-05-31
Rated 5 out of 5 by DM in UW from Good antibodythis antibody works well for IHC on human tissue of paraffin section at a 1:500 dilution
Date published: 2017-02-21
Rated 4 out of 5 by 我就是我 from Strip is not clear.Last year I purchased p120 sc-23873 sample. When doing human umbilical vein endothelial cells protein blotting, the results in the band is not very clear.I will try immunohistochemistry later.
Date published: 2017-02-21
Rated 5 out of 5 by Germaine from Highly recommended p120 monoclonalThis is the best p120 monoclonal antibody for a variety of application and species. Great clean strong bands in WB on MDCK, NRK, PC-12, EOC 20 and AMJ2-C8 whole cell lysates. Beautiful immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder and human bronchus tissue.
Date published: 2017-01-20
Rated 5 out of 5 by Tuier from Works wellImmunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization,dyeing effect is very good, recommend the use of.
Date published: 2016-12-17
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p120 抗体 (6H11) is rated 4.6 out of 5 by 14.
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