p-VASP Antibody (5C6): sc-101440
- p-VASP Antibody (5C6) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against synthetic VASP of human origin, phosphorylated at serine 157
- recommended for detection of Ser 157 phosphorylated VASP of mouse, rat and human origin by WB, IP, IF, FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-VASP Antibody (5C6). This work is in progress.
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p-VASP Antibody (5C6) is a mouse monoclonal IgG1 antibody that detects VASP in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). anti-VASP antibody (5C6) specifically recognizes the phosphorylated form of VASP, which plays a crucial role in the regulation of actin dynamics and cellular architecture. VASP is primarily located in focal adhesions and microfilaments, where VASP interacts with actin filaments to facilitate cellular processes such as migration and adhesion. This localization is vital as VASP responds to extracellular signals and coordinates the cytoskeletal rearrangements necessary for cell movement and stability. Additionally, VASP undergoes post-translational modifications, including phosphorylation at serine residues, which modulate VASP activity and interactions with other proteins. VASP′s ability to undergo these modifications is essential for function in signal transduction pathways, making VASP a key player in various physiological processes and a significant focus in studies related to cell motility and cancer metastasis.
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p-VASP Antibody (5C6) References:
- Phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) by the anti-platelet drug, cilostazol, in platelets. | Sudo, T., et al. 2003. Platelets. 14: 381-90. PMID: 14602552
- Phosphorylated vasodilator-stimulated phosphoprotein is localized on mitotic spindles of the gastric cancer cell line SGC-7901. | Tao, Y., et al. 2006. World J Gastroenterol. 12: 7478-81. PMID: 17167837
- Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation. | Lee, S. and Chung, CY. 2009. Mol Cell Neurosci. 42: 382-90. PMID: 19733667
- Neutrophil beta2 integrin inhibition by enhanced interactions of vasodilator-stimulated phosphoprotein with S-nitrosylated actin. | Thom, SR., et al. 2011. J Biol Chem. 286: 32854-65. PMID: 21795685
- 'VASPFix' for measurement of VASP phosphorylation in platelets and for monitoring effects of P2Y12 antagonists. | Glenn, JR., et al. 2014. Thromb Haemost. 111: 539-48. PMID: 24258486
- Prenatal carbon monoxide impairs migration of interneurons into the cerebral cortex. | Trentini, JF., et al. 2016. Neurotoxicology. 53: 31-44. PMID: 26582457
- The Increase of pFAK and THBS1 Protein and Gene Expression Levels in Vascular Smooth Muscle Cells by Histamine-treated M1 Macrophages. | Khosravi, M., et al. 2019. Iran J Allergy Asthma Immunol. 18: 72-79. PMID: 30848575
- Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma. | Huang, F., et al. 2020. Cancer Lett. 479: 100-111. PMID: 32200035
- Exploring the oncogenic role of RGS19 in bladder cancer progression and prognosis. | Yan, L., et al. 2024. Acta Histochem. 126: 152212. PMID: 39481225
- Dephosphorylation of the focal adhesion protein VASP in vitro and in intact human platelets. | Abel, K., et al. 1995. FEBS Lett. 370: 184-8. PMID: 7656973
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-VASP Antibody (5C6) | sc-101440 | 50 µg/0.5 ml | $322.00 |