p-p120 Antibody (pY96.6A): sc-293017

p-p120 Antibody (pY96.6A) is a mouse monoclonal IgG1 antibody that detects p120 in mouse, rat, and human samples through western blotting (WB). Anti-p120 antibody (pY96.6A) specifically recognizes the phosphorylated form of p120, a crucial protein that plays a significant role in cellular adhesion and signaling pathways. Located primarily in the cytoplasm, nucleus, and cell membrane, p120 is essential for mediating interactions between cadherins and catenins, which are vital for maintaining tissue integrity and regulating cell behavior. The phosphorylation of p120, particularly at tyrosine residues, modulates interactions with other proteins and influences downstream signaling pathways, including those activated by epidermal growth factor and platelet-derived growth factor receptors. This post-translational modification can affect cellular processes such as proliferation, migration, and differentiation, making p120 a key player in various physiological and pathological conditions. With interactions across multiple signaling molecules and involvement in critical cellular functions, p120 serves as a valuable target for research in cancer biology and developmental studies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

p-p120 Antibody (pY96.6A) References:

1. p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligation.  |  Xia, X., et al. 2006. Exp Cell Res. 312: 3336-48. PMID: 16935280
2. Generation and characterization of a novel phospho-specific monoclonal antibody to p120-catenin serine 879.  |  Vaughan, MH., et al. 2007. Hybridoma (Larchmt). 26: 407-15. PMID: 18158786
3. PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway.  |  Brown, MV., et al. 2009. Exp Cell Res. 315: 39-49. PMID: 18950621
4. Insulin receptors in developing rat liver. Receptor autophosphorylation and phosphorylation of the endogenous substrate pp120/HA4 (ecto-ATPase) in fetal and neonatal liver.  |  Margolis, RN., et al. 1990. Biol Neonate. 58: 227-35. PMID: 2148694
5. Phosphorylated p120-catenin expression has predictive value for oral cancer progression.  |  Ma, LW., et al. 2012. J Clin Pathol. 65: 315-9. PMID: 22259181
6. Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase.  |  Formisano, P., et al. 1995. J Biol Chem. 270: 24073-7. PMID: 7592607
7. pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms.  |  Najjar, SM., et al. 1993. J Biol Chem. 268: 1201-6. PMID: 8380406
8. Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: role for the C-terminal domain of the beta-subunit.  |  Najjar, SM., et al. 1997. Biochemistry. 36: 6827-34. PMID: 9184166
9. B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation.  |  Nakamura, K. and Cambier, JC. 1998. J Immunol. 161: 684-91. PMID: 9670943
10. Insulin stimulates pp120 endocytosis in cells co-expressing insulin receptors.  |  Choice, CV., et al. 1998. J Biol Chem. 273: 22194-200. PMID: 9712832

The preferred p120 antibody is p120 Antibody (15D2): sc-23872.