p-p120 Antibody (pY280.18): sc-136016

p-p120 Antibody (pY280.18) is a mouse monoclonal IgG1 antibody that detects p120 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p120, also known as cadherin-associated Src substrate, is a crucial protein that plays a significant role in cellular adhesion by interacting with E-cadherin and other catenins. p120 is primarily located in the cytoplasm, nucleus, and cell membrane of vascular endothelial cells, which is vital for mediating cell signaling and maintaining tissue integrity. p120 participates in ligand-induced receptor signaling pathways involving epidermal growth factor, platelet-derived growth factor, colony-stimulating factor-1, and Neu receptors, thereby influencing various cellular processes such as proliferation and differentiation. p120 undergoes post-translational modifications, including phosphorylation, which can modulate activity and interactions with other proteins. With four major isoforms resulting from alternative splicing, p120 exhibits a complex regulatory mechanism essential for diverse functions in cellular signaling and adhesion. anti-p120 antibody (pY280.18) is an invaluable tool for researchers studying p120′s intricate roles in cellular dynamics and implications in various biological processes.

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p-p120 Antibody (pY280.18) References:

1. The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor.  |  Soni, P., et al. 2000. Mol Cell Biol. 20: 3896-905. PMID: 10805733
2. Serine and threonine phospho-specific antibodies to p120-catenin.  |  Xia, X., et al. 2004. Hybrid Hybridomics. 23: 343-51. PMID: 15684660
3. Hepatocyte plasma membrane ECTO-ATPase (pp120/HA4) is a substrate for tyrosine kinase activity of the insulin receptor.  |  Margolis, RN., et al. 1990. Biochem Biophys Res Commun. 166: 562-6. PMID: 2137339
4. Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model.  |  Maiden, SL., et al. 2016. PLoS One. 11: e0148574. PMID: 26845024
5. As human lung microvascular endothelia achieve confluence, src family kinases are activated, and tyrosine-phosphorylated p120 catenin physically couples NEU1 sialidase to CD31.  |  Hyun, SW., et al. 2017. Cell Signal. 35: 1-15. PMID: 28343945
6. Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase.  |  Najjar, SM., et al. 1995. Biochemistry. 34: 9341-9. PMID: 7626603
7. Cloning and characterization of a functional promoter of the rat pp120 gene, encoding a substrate of the insulin receptor tyrosine kinase.  |  Najjar, SM., et al. 1996. J Biol Chem. 271: 8809-17. PMID: 8621519
8. Differential effect of pp120 on insulin endocytosis by two variant insulin receptor isoforms.  |  Li Calzi, S., et al. 1997. Am J Physiol. 273: E801-8. PMID: 9357811
9. Effect of pp120 on receptor-mediated insulin endocytosis is regulated by the juxtamembrane domain of the insulin receptor.  |  Najjar, SM., et al. 1998. J Biol Chem. 273: 12923-8. PMID: 9582324
10. pp120, a substrate of the insulin receptor tyrosine kinase, is associated with phosphatase activity.  |  Najjar, SM. 1998. Biochem Biophys Res Commun. 247: 457-61. PMID: 9642150

The preferred p120 antibody is p120 Antibody (15D2): sc-23872.