p-EGFR Antibody (6D373): sc-71778

p-EGFR Antibody (6D373) is a mouse monoclonal IgG1 antibody that detects synthetic phosphopeptide corresponding to amino acid residues surrounding Serine 1047 of EGFR of human origin in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-p-EGFR antibody (6D373) recognizes phosphorylated forms of EGFR, which is crucial for mediating cellular responses to growth factors. EGFR is primarily located on the cell surface, where binding with ligands like epidermal growth factor (EGF) or transforming growth factor alpha (TGFα) triggers dimerization and autophosphorylation. This activation initiates a cascade of downstream signaling pathways that regulate cell proliferation, differentiation, and survival, making EGFR a vital component in various physiological processes and a key player in oncogenesis when dysregulated. Phosphorylation of specific tyrosine residues, such as Tyr 1092 and Tyr 1173, enables recruitment of signaling proteins like GRB2, which further propagate the signaling cascade. Understanding EGFR activation dynamics and interactions remains critical for developing targeted cancer therapies, as aberrant EGFR signaling appears in numerous malignancies. p-EGFR monoclonal antibody (6D373) serves as an indispensable tool for studying EGFR phosphorylation and signaling, advancing our understanding of EGFR function in both normal physiology and cancer biology.

The preferred EGFR antibody is EGFR Antibody (528): sc-120.