Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
BRCA1 is a cell cycle-regulated nuclear protein that is phosphorylated mainly on serine and to a lesser extent on threonine residues. Changes in phosphorylation occur in response to cell cycle progression and DNA damage. BRCA1 undergoes hyperphosphorylation during late G1 and S phases of the cell cycle. BRCA1 is a substrate of ATM kinase, and phosphorylation of BRCA1 requires the presence of a functional ATM protein. Chk2 regulates BRCA1 function after DNA damage by phosphorylating Serine 988 of BRCA1. This phosphorylation is required for the release of BRCA1 from Chk2 and the ability of BRCA1 to restore survival after DNA damage. BRCA1 is also phosphorylated at Serine 1497, which is part of a cyclin-dependent kinase consensus site.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences