p-Bcl-2 Antibody (A-3): sc-377513

p-Bcl-2 Antibody (A-3) is a mouse monoclonal IgG2b antibody that detects p-Bcl-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-p-Bcl-2 antibody (A-3) specifically targets phosphorylated forms of Bcl-2, which plays a crucial role in regulating apoptosis, a vital process for maintaining cellular homeostasis and protecting against diseases, including cancer. p-Bcl-2 (A-3) antibody recognizes Bcl-2 primarily in the outer mitochondrial membrane, where Bcl-2 functions to inhibit apoptosis by preventing the release of pro-apoptotic factors, such as cytochrome c, into the cytosol. This localization is significant because Bcl-2 effectively modulates the intrinsic apoptotic pathway, thereby influencing cell survival in response to various stress signals. Dysregulation of Bcl-2, often due to mutations or aberrant expression, can lead to uncontrolled cell proliferation and resistance to apoptosis, contributing to the development of several malignancies. Using p-Bcl-2 monoclonal antibody (A-3) in research can provide insights into apoptosis mechanisms and Bcl-2′s role in cancer biology, ultimately aiding in the development of targeted therapies.

The preferred Bcl-2 antibody is Bcl-2 Antibody (C-2): sc-7382.