Oxatomide CAS: 60607-34-3
MF: C27H30N4O
MW: 426.55
An H1-histamine receptor antagonist.

Oxatomide (CAS 60607-34-3)

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备用名: 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one
应用; Oxatomide is an H1-histamine receptor antagonist
CAS号码: 60607-34-3
纯度: 99%
分子量: 426.55
分子式: C27H30N4O
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Oxatomide is a phenylpiperazine which acts as an H1 receptor antagonist. An interesting characteristic of Oxatomide is that it does not block acetylcholine in the central and peripheral nervous system. Studies conducted on guinea pigs show that Oxatomide suppresses PAF-induced bronchoconstriction and inhibits the release of leukotrienes and other mediators. Alternate studies show that the effectiveness of Oxatomide is not altered as a result of pretreating the cells with histamine, which is observed in other H1 receptor antagonists such as Fexofenadine (sc-218475). It is believed that Oxatomide's lipophilic properties allow it to cross the plasma membrane of cells.


参考文献

1. Ohmori, K., et al. 1983. Nippon Yakurigaku Zasshi. 81: 399-409. PMID: 6138301
2. Hishinuma, S., et al. 2008. J. Pharmacol. Sci. 107: 66-79. PMID: 18446005

外观 :
Crystalline powder
物理状态 :
Solid
溶解度 :
Soluble in DMSO, ethanol, methanol, water, and chloroform.
保存 :
Store at 4° C
熔点 :
153-154° C
沸点 :
621.1° C
密度 :
1.18 g/cm3
折射率 :
n20D 1.62
光学活性 :
α20/D +3°, c = 0.4 in water
IC50 :
Histamine H1 Receptor: IC50 = 9 nM (human); Plasmodium falciparum: IC50 = 3.98 µM; Cavia porcellus: IC50 = 20.1 µM
pK值 :
pKa: 12.2 (Predicted), pKb: 7.5 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
DE2276000
PubChem CID :
4615
默克索引 :
14: 6925
MDL 号码 :
MFCD00211147
EC号码 :
262-320-9
Beilstein 注册 :
4724760
SMILES :
C1CN(CCN1CCCN2C3=CC=CC=C3NC2=O)C(C4=CC=CC=C4)5=CC=CC=C5

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