Nigericin sodium salt CAS: 28643-80-3
MF: C40H67O11•Na
MW: 746.94
A polyether antibioitc K+ and Na+ ionophore.

Nigericin sodium salt (CAS 28643-80-3)

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同义词: Antibiotic K 178
应用; A polyether antibioitc K+ and Na+ ionophore
CAS号码: 28643-80-3
纯度: 98%
分子量: 746.94
分子式: C40H67O11•Na
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
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Nigericin sodium salt, a polyether antibiotic K+ and Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential and stimulates ATPase activity leading to rapid intracellular acidification resulting in apoptosis. Nigericin•Na has shown a role for inducing caspase-1-independent necrotic cell death. Nigericin•Na has also been found to increase membrane potential accelerating the rate of superoxide generation approaching the rate obtained by antimycin. Nigericin•Na is an activator of Cryopyrin.


参考文献

1. Vercesi, A.E., et al. 1993. J. Biol. Chem. 268: 8564-8568. PMID: 8473301
2. Furlong, I.J., et al. 1997. J. Cell Sci. 110: 653-661. PMID: 9092947
3. Sze, H. 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 5904-5908. PMID: 16592894
4. Hentze, H., et al. 2003. Cell Death Differ. 10: 956-968. PMID: 12934070
5. Rottenberg, H., et al. 2009. J. Biol. Chem. 284: 19203-19210. PMID: 19478336
6. Sze, H. 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 5904-5908. PMID: 16592894

物理状态 :
Solid
来源于 :
Streptomyes hygroscopicus
溶解度 :
Soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), dichloromethane (10 mg/ml), and methanol (10 mg/ml).
保存 :
Store at -20° C
折射率 :
n20D 1.54
IC50 :
Plasmodium yoelii yoelii: IC50 = <0.001 nM; H9: IC50 = 140 nM (human); immunodeficiency virus 1: EC5050 = 6 nM (human)
pK值 :
pKa: 4.39
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
QT6825000
PubChem CID :
16760591
默克索引 :
14: 6541
MDL 号码 :
MFCD00036825
Beilstein 注册 :
3892398

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引用1 - 33

PMID: # 28938395  Pal, PB. et al. 2017. Endocrinology. 158: 3661-3675.

PMID: # 19478336  Rottenberg, H. et al. 2009. J. Biol. Chem.

PMID: # 17606922  Kikawada, T. et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 11585-11590.

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