Date published: 2025-9-6

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MZF-1 抗体 (1F7): sc-293218

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说明书
  • MZF-1 抗体 1F7 是小鼠单克隆 IgG1 κ,MZF-1抗体, 在4篇文献中引用,规格为100 µg/ml
  • 针对部分重组蛋白,其氨基酸序列在MZF-1的human起源的419-518范围内
  • 推荐用于 human 来源的MZF-1 WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取MZF-1 (1F7): sc-293218免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成MZF-1 抗体 (1F7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

MZF-1抗体(1F7)是一种鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学和酶联免疫吸附测定(ELISA)检测人类MZF-1蛋白。抗MZF-1抗体(1F7)以非结合形式提供。髓样锌指蛋白1(MZF-1)也称为锌指蛋白42或转录因子ZBP-89,是克鲁佩尔C2H2型锌指蛋白家族的一员,在基因表达调控中起着至关重要的作用。MZF-1主要位于细胞核中,在造血发育和髓样细胞分化过程中,MZF-1发挥转录调控的作用。MZF-1的核定位对于以组织特异性方式调节目标基因(包括CD34启动子)的转录至关重要。MZF-1由维甲酸诱导,主要在分化中的髓样细胞中表达,这凸显了MZF-1在造血中的重要性。此外,MZF-1还可以与其他核蛋白形成高分子复合物,进一步强调了MZF-1在转录调控和细胞分化过程中的作用。编码MZF-1的基因位于19q13.43染色体上,这强调了MZF-1在人类生物学中的遗传意义。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MZF-1 抗体 (1F7) 参考文献:

  1. 多种抗叶酸的肿瘤细胞系中叶酸载体基因沉默的减少是由于多种转录因子同时丧失功能,而不是启动子甲基化。  |  Rothem, L., et al. 2004. J Biol Chem. 279: 374-84. PMID: 14551190
  2. 与肿瘤坏死因子-α 启动子中 -308 单核苷酸多态性位点的等位基因特异性结合。  |  Baseggio, L., et al. 2004. Eur J Immunogenet. 31: 15-9. PMID: 15009176
  3. TAIL1:isthmin 样基因,含有 1 型凝血酶原重复序列和 AMOP 结构域,映射到 ARVD1 临界区。  |  Rossi, V., et al. 2004. Gene. 335: 101-8. PMID: 15194193
  4. FHL3 作为 MZF-1 的转录共抑制因子,负向调控人类高亲和性 IgE 受体 beta 链基因的表达。  |  Takahashi, K., et al. 2005. Biochem J. 386: 191-200. PMID: 15453830
  5. LDOC1是一种新型MZF-1相互作用蛋白,可诱导细胞凋亡。  |  Inoue, M., et al. 2005. FEBS Lett. 579: 604-8. PMID: 15670815
  6. 视黄酸反应型人类锌指基因 MZF-1 在骨髓细胞中优先表达。  |  Hromas, R., et al. 1991. J Biol Chem. 266: 14183-7. PMID: 1860835
  7. 蛋白激酶 C α及 MZF-1 和 Elk-1 转录因子在人类乳腺癌细胞中的表达  |  Yue, CH., et al. 2012. Chin J Physiol. 55: 31-6. PMID: 22242952
  8. 髓质锌指1(MZF-1)通过强化铁蛋白传导的铁排出抑制前列腺肿瘤的生长。  |  Chen, Y., et al. 2015. Oncogene. 34: 3839-47. PMID: 25284586
  9. MZF-1/Elk-1/PKCα与肝细胞癌患者的不良预后相关。  |  Ye, JC., et al. 2017. J Cancer. 8: 3028-3036. PMID: 28928894
  10. 通过转录因子 E2F1 和 MZF-1 调节 MLAA-34 基因的表达。  |  Lei, B., et al. 2019. Int J Clin Exp Pathol. 12: 2100-2110. PMID: 31934032
  11. 抑制 BET 可增加 βIII-tubulin 的表达,并使脑部转移性乳腺癌对长春瑞滨敏感。  |  Kanojia, D., et al. 2020. Sci Transl Med. 12: PMID: 32848091
  12. 骨髓锌指基因 MZF-1 在体外调节 CD34 启动子。  |  Morris, JF., et al. 1995. Blood. 86: 3640-7. PMID: 7579328

订购信息

产品名称产品编号规格价格数量收藏夹

MZF-1 抗体 (1F7)

sc-293218
100 µg/ml
$316.00

Will this MZF-1 antibody react with mouse or rat ? Thank you,

Asked by: Coralie P
Thank you for your question. We do not yet have any data or citations in mouse, so this antibody is not currently recommended for that species. Please contact our Technical Service Department for assistance with sequence analysis to predict potential cross-reactivity with other species.
Answered by: Technical Support
Date published: 2019-09-23

Can sc-293218: MZF-1 (1F7) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Dr Ninau Qelp
Thank you for your question. Yes, sc-293218: MZF-1 (1F7) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 4 out of 5 by from Great for WBThis primary antibody is useful in western blotting.
Date published: 2024-03-20
Rated 5 out of 5 by from Good for Western BlotAntibody works for Western blot with A549 and BEAS 2B cell lysates, expression is enhanced 3-48 hr post 6 Gy irradiation in published research -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from MZF1 antibodynice antibody for WB assay using human prostate canecr cell lines.
Date published: 2022-08-22
Rated 5 out of 5 by from GreatThis production is very great with high quanlity and high specificity.
Date published: 2016-11-19
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MZF-1 抗体 (1F7) is rated 4.8 out of 5 by 4.
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