Myoseverin (CAS 267402-71-1)
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Myoseverin is a chemical compound that functions as a potent inhibitor of microtubule polymerization. It disrupts the dynamic instability of microtubules by binding to the colchicine site, leading to the depolymerization of microtubules. Myoseverin interferes with the normal assembly and disassembly of microtubules, ultimately disrupting cellular processes that rely on microtubule dynamics. By targeting the colchicine site, Myoseverin specifically inhibits the growth of microtubules, affecting their structural integrity and function within the cell. This disruption of microtubule dynamics can have significant implications for cellular processes such as mitosis, intracellular transport, and cell motility. Its ability to specifically target the colchicine site may be a useful for studying the role of microtubules in various cellular processes.
Myoseverin (CAS 267402-71-1) References
- Myoseverin, a microtubule-binding molecule with novel cellular effects. | Rosania, GR., et al. 2000. Nat Biotechnol. 18: 304-8. PMID: 10700146
- Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors. | Chang, YT., et al. 2001. J Med Chem. 44: 4497-500. PMID: 11741468
- Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors. | Perez, OD., et al. 2002. Chem Biol. 9: 475-83. PMID: 11983336
- Tubulyzine, a novel tri-substituted triazine, prevents the early cell death of transplanted myogenic cells and improves transplantation success. | El Fahime, E., et al. 2003. Biochem Cell Biol. 81: 81-90. PMID: 12870872
- Distinctive expression of Myf5 in relation to differentiation and plasticity of newt muscle cells. | Imokawa, Y., et al. 2004. Int J Dev Biol. 48: 285-91. PMID: 15300509
- A single-cell analysis of myogenic dedifferentiation induced by small molecules. | Duckmanton, A., et al. 2005. Chem Biol. 12: 1117-26. PMID: 16242654
- Determination of myoseverin embryotoxic potential by using FETAX. | Vismara, C., et al. 2006. Birth Defects Res B Dev Reprod Toxicol. 77: 257-67. PMID: 16929549
- Myoseverin is a potential angiogenesis inhibitor by inhibiting endothelial cell function and endothelial progenitor cell differentiation. | Park, HE., et al. 2006. DNA Cell Biol. 25: 514-22. PMID: 16989574
- Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin. | Krystof, V., et al. 2006. Eur J Med Chem. 41: 1405-11. PMID: 16996651
- Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition. | Ng, DC., et al. 2008. Cell Motil Cytoskeleton. 65: 40-58. PMID: 17948234
- Evaluation of novel microtubules interfering agents myoseverin, tubulyzine and E2GG in primary cultures of rat hepatocytes. | Dvorák, Z., et al. 2007. Gen Physiol Biophys. 26: 173-80. PMID: 18063844
- Control of muscle differentiation by a mitochondria-targeted fluorophore. | Kim, YK., et al. 2010. J Am Chem Soc. 132: 576-9. PMID: 20020712
- Novel chemically defined approach to produce multipotent cells from terminally differentiated tissue syncytia. | Jung, DW. and Williams, DR. 2011. ACS Chem Biol. 6: 553-62. PMID: 21322636
- Small molecules that recapitulate the early steps of urodele amphibian limb regeneration and confer multipotency. | Kim, WH., et al. 2012. ACS Chem Biol. 7: 732-43. PMID: 22270490
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myoseverin, 1 mg | sc-203146 | 1 mg | $33.00 |