MTMR2 Antibody (B-6): sc-365185
- MTMR2 Antibody (B-6) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 47-77 near the N-terminus of MTMR2 of human origin
- recommended for detection of MTMR2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MTMR2 Antibody (B-6) for WB applications. These reagents are now offered in bundles with MTMR2 Antibody (B-6) (see ordering information below).
MTMR2 Antibody (B-6) is a mouse monoclonal IgG2a antibody that detects myotubularin 2 (MTMR2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MTMR2 plays a crucial role in cellular signaling and membrane dynamics as a phosphatase that specifically hydrolyzes inositol phospholipids, including Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2, which are vital for various cellular processes such as endocytosis and autophagy. The importance of MTMR2 is underscored by involvement in the pathogenesis of autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), a hereditary neuropathy characterized by demyelination and reduced nerve conduction velocities, highlighting MTMR2′s essential function in maintaining neuronal integrity. Additionally, MTMR2′s interactions with other members of the myotubularin-related protein family, such as MTMR5, which enhances enzymatic activity and influences localization within the cell, further illustrate the complexity of regulatory mechanisms. MTMR2 (B-6) antibody is an invaluable tool for researchers investigating the roles of myotubularin and related proteins in both normal physiology and disease states.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTMR2 Antibody (B-6) | sc-365185 | 200 µg/ml | $322.00 | |||
MTMR2 Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-537785 | 200 µg Ab; 10 µg BP | $361.00 | |||
MTMR2 Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-535171 | 200 µg Ab; 40 µg BP | $361.00 | |||
MTMR2 Antibody (B-6): m-IgG2a BP-HRP Bundle | sc-548122 | 200 µg Ab; 10 µg BP | $361.00 | |||
MTMR2 (B-6) Neutralizing Peptide | sc-365185 P | 100 µg/0.5 ml | $69.00 |