MSK2 Antibody (2934C1a): sc-130653
- MSK2 Antibody (2934C1a) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the C-terminus of MSK2 of human origin
- recommended for detection of MSK2 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MSK2 Antibody (2934C1a). This work is in progress.
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MSK2 Antibody (2934C1a) is a mouse monoclonal IgG1 antibody that detects MSK2 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. MSK2, also known as RPS6KA4 or RSKB, is a crucial serine/threonine protein kinase composed of 772 amino acids, primarily localized in the nucleus. MSK2 plays a significant role in cellular signaling pathways, particularly in the regulation of growth-factor and stress-induced transcriptional activation. By utilizing magnesium as a cofactor, MSK2 catalyzes the ATP-dependent phosphorylation of target proteins, thereby influencing various cellular functions such as cell division, homeostasis, and apoptosis. MSK2′s nuclear localization enables direct interaction with transcription factors and other regulatory proteins, facilitating precise modulation of gene expression in response to external stimuli. Additionally, MSK2 is subject to alternative splicing, resulting in multiple isoforms that may have distinct regulatory roles, further underscoring the complexity of MSK2′s function in cellular signaling networks. Anti-MSK2 antibody (2934C1a) is an invaluable tool for researchers investigating the intricate mechanisms of cellular regulation and signaling pathways.
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MSK2 Antibody (2934C1a) References:
- MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. | Wiggin, GR., et al. 2002. Mol Cell Biol. 22: 2871-81. PMID: 11909979
- MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. | Soloaga, A., et al. 2003. EMBO J. 22: 2788-97. PMID: 12773393
- MSK1 and MSK2 mediate mitogen- and stress-induced phosphorylation of histone H3: a controversy resolved. | Davie, JR. 2003. Sci STKE. 2003: PE33. PMID: 12915720
- The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. | Ananieva, O., et al. 2008. Nat Immunol. 9: 1028-36. PMID: 18690222
- MSK2 inhibits p53 activity in the absence of stress. | Llanos, S., et al. 2009. Sci Signal. 2: ra57. PMID: 19797274
- miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy. | Badal, SS., et al. 2016. Nat Commun. 7: 12076. PMID: 27350436
- Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2. | Reyskens, KM. and Arthur, JS. 2016. Front Cell Dev Biol. 4: 56. PMID: 27376065
- MSK2 promotes proliferation and tumor formation in squamous cervical cancer via PAX8/RB-E2F1/cyclin A2 axis. | Wu, Y., et al. 2019. J Cell Biochem. 120: 11432-11440. PMID: 30756420
- Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer. | Jin, G., et al. 2020. Oncogene. 39: 6733-6746. PMID: 32963350
- Growth factor-induced activation of MSK2 leads to phosphorylation of H3K9me2S10 and corresponding changes in gene expression. | Wong, KG., et al. 2024. Sci Adv. 10: eadm9518. PMID: 38478612
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MSK2 Antibody (2934C1a) | sc-130653 | 100 µg/ml | $339.00 |