MRP-L41 Antibody (H-10): sc-514312
- MRP-L41 Antibody (H-10) is a mouse monoclonal IgG1 κ MRP-L41 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 9-117 mapping within an internal region of MRP-L41 of human origin
- MRP-L41 Antibody (H-10) is recommended for detection of MRP-L41 of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-MRP-L41 Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MRP-L41 Antibody (H-10) for WB applications. These reagents are now offered in bundles with MRP-L41 Antibody (H-10) (see ordering information below).
MRP-L41 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects MRP-L41 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MRP-L41 (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MRP-L41, also known as Cell proliferation-inducing gene 3 protein and BMRP (Bcl-2-interacting mitochondrial ribosomal protein L41), is a crucial component of the mitochondrial ribosome, specifically part of the large 39S subunit, which plays a vital role in mitochondrial protein synthesis. This 137 amino acid protein is predominantly localized in the mitochondrion and is expressed in key tissues such as the liver, testis, kidney, and thymus. MRP-L41 is not only essential for the assembly of mitochondrial ribosomes but also significantly influences cellular processes, including the cell cycle and apoptosis. MRP-L41 has been shown to stabilize the cyclin-dependent kinase inhibitors p21 and p27, thereby facilitating cell cycle arrest in the G1 phase. Additionally, MRP-L41 enhances the stability of the tumor suppressor protein p53, contributing to p53-mediated apoptosis under growth-inhibitory conditions, highlighting its importance in cellular response to stress and regulation of cell proliferation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MRP-L41 Antibody (H-10) References:
- Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. | Suzuki, T., et al. 2001. J Biol Chem. 276: 21724-36. PMID: 11279069
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. | Kenmochi, N., et al. 2001. Genomics. 77: 65-70. PMID: 11543634
- The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. | Koc, EC., et al. 2001. J Biol Chem. 276: 43958-69. PMID: 11551941
- BMRP is a Bcl-2 binding protein that induces apoptosis. | Chintharlapalli, SR., et al. 2005. J Cell Biochem. 94: 611-26. PMID: 15547950
- Nuclear MRP genes and mitochondrial disease. | O'Brien, TW., et al. 2005. Gene. 354: 147-51. PMID: 15908146
- Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1. | Yoo, YA., et al. 2005. Mol Cell Biol. 25: 6603-16. PMID: 16024796
- Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). | Kim, MJ., et al. 2005. Biochem Biophys Res Commun. 338: 1179-84. PMID: 16256947
- Mitochondrial ribosomal proteins (MRPs) of yeast. | Graack, HR. and Wittmann-Liebold, B. 1998. Biochem J. 329 (Pt 3): 433-48. PMID: 9445368
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP-L41 Antibody (H-10) | sc-514312 | 200 µg/ml | $322.00 | |||
MRP-L41 Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-527884 | 200 µg Ab; 10 µg BP | $361.00 | |||
MRP-L41 Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-533257 | 200 µg Ab; 20 µg BP | $361.00 | |||
MRP-L41 Antibody (H-10) AC | sc-514312 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MRP-L41 Antibody (H-10) HRP | sc-514312 HRP | 200 µg/ml | $322.00 | |||
MRP-L41 Antibody (H-10) FITC | sc-514312 FITC | 200 µg/ml | $336.00 | |||
MRP-L41 Antibody (H-10) PE | sc-514312 PE | 200 µg/ml | $349.00 | |||
MRP-L41 Antibody (H-10) Alexa Fluor® 488 | sc-514312 AF488 | 200 µg/ml | $364.00 | |||
MRP-L41 Antibody (H-10) Alexa Fluor® 546 | sc-514312 AF546 | 200 µg/ml | $364.00 | |||
MRP-L41 Antibody (H-10) Alexa Fluor® 594 | sc-514312 AF594 | 200 µg/ml | $364.00 | |||
MRP-L41 Antibody (H-10) Alexa Fluor® 647 | sc-514312 AF647 | 200 µg/ml | $364.00 | |||
MRP-L41 Antibody (H-10) Alexa Fluor® 680 | sc-514312 AF680 | 200 µg/ml | $364.00 | |||
MRP-L41 Antibody (H-10) Alexa Fluor® 790 | sc-514312 AF790 | 200 µg/ml | $364.00 |