Date published: 2025-9-6

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MYL12A/B 抗体 (A-10): sc-376606

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说明书
  • MYL12A/B抗体(A-10)是小鼠单克隆IgG2b κ, 在4篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的MRCL3的内部区域内的氨基酸103-141之间
  • MYL12A/B 抗体 (A-10) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测 the myosin regulatory light chains encoded by MYL12A and MYL12B of human origin, Mylc2b of mouse origin and Mrlcb of rat origin ; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • 抗MYL12A/B抗体(A-10)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取MYL12A/B (A-10): sc-376606免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG2b BP-HRP 是 MYL12A/B 抗体 (A-10) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与MYL12A/B 抗体 (A-10) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

MYL12A/B抗体(A-10)是一种IgG2b κ小鼠单克隆MYL12A/B抗体,可通过WB、IP、IF、IHC(P)和ELISA方法检测人源MYL12A和MYL12B、鼠源Mylc2b以及鼠、大鼠和人源大鼠Mrlcb编码的肌球蛋白调节轻链。MYL12A/B抗体(A-10)既有非偶联形式的抗MYL12A/B抗体,也有多种偶联形式的抗MYL12A/B抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。肌球蛋白是一种高度保守、普遍表达的蛋白质,与肌动蛋白相互作用产生细胞运动所需的力。常规肌球蛋白是六聚体蛋白质,由两个重链亚基、一对非磷酸化轻链亚基和一对可磷酸化轻链亚基组成。目前已克隆出三类肌球蛋白:平滑肌肌球蛋白、横纹肌肌球蛋白和非肌球蛋白。肌球蛋白调节轻链,包括MYL12A(也称为MRLC3或MLCB)、MYL12B(也称为MRLC2)和MYL9(也称为LC20、MLC2、MRLC1或MYRL2),通过肌球蛋白轻链激酶(MLCK)的磷酸化作用调节平滑肌和非肌细胞的收缩。在钙和钙调蛋白存在下,MLCK催化肌球蛋白调节轻链的磷酸化,增加肌动蛋白激活的肌球蛋白ATP酶活性,从而调节收缩活性。肌球蛋白轻链也存在于横纹肌中,但其功能尚未确定。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MYL12A/B 抗体 (A-10) 参考文献:

  1. 抑制 Rho- 缔合激酶可阻断激动剂诱导的 Ca2+ 对豚鼠回肠肌球蛋白磷酸化和肌力的敏感性。  |  Swärd, K., et al. 2000. J Physiol. 522 Pt 1: 33-49. PMID: 10618150
  2. 平滑肌肌球蛋白轻链激酶 C 端结构域对平滑肌肌球蛋白磷酸化的功能作用  |  Numata, T., et al. 2001. J Biochem. 129: 437-44. PMID: 11226884
  3. Rho 激酶介导血清诱导的成纤维细胞纤维收缩,与肌球蛋白 LC20 磷酸化无关。  |  Nobe, H., et al. 2003. Am J Physiol Cell Physiol. 284: C599-606. PMID: 12388108
  4. ERK 介导的子宫动脉收缩:粗丝和细丝调节途径的作用。  |  Xiao, D., et al. 2004. Am J Physiol Heart Circ Physiol. 286: H1615-22. PMID: 15072969
  5. 导致家族性肥厚型心肌病的肌球蛋白 RLC 的 E22K 突变会增加转基因小鼠对钙的敏感性和 ATP 酶。  |  Szczesna-Cordary, D., et al. 2005. J Cell Sci. 118: 3675-83. PMID: 16076902
  6. 与整合素相连的激酶负责血管平滑肌不依赖于 Ca2+ 的肌球蛋白二磷酸化和收缩。  |  Wilson, DP., et al. 2005. Biochem J. 392: 641-8. PMID: 16201970
  7. 先天性大鼠气道高反应性的平滑肌肌球蛋白同工酶表达和 LC20 磷酸化  |  Gil, FR., et al. 2006. Am J Physiol Lung Cell Mol Physiol. 291: L932-40. PMID: 16766577
  8. 肌球蛋白调节轻链是维持肌球蛋白II稳定性和细胞完整性的必要条件。  |  Park, I., et al. 2011. Biochem J. 434: 171-80. PMID: 21126233
  9. 人血管平滑肌肌球蛋白轻链 2 同工酶在非肌肉细胞中的特征和差异表达。  |  Kumar, CC., et al. 1989. Biochemistry. 28: 4027-35. PMID: 2526655
  10. 使用定量蛋白质组学方法鉴定磷酸化MYL12B作为脓毒症急性肾损伤的潜在血浆生物标志物。  |  Wu, F., et al. 2015. Int J Clin Exp Pathol. 8: 14409-16. PMID: 26823757
  11. 鲁帕他定抑制的OTUD3通过去泛素化MYL12A和PD-L1促进DLBCL进展和免疫逃逸。  |  Sui, Y., et al. 2024. Cell Death Dis. 15: 561. PMID: 39097608
  12. 鸡胚成纤维细胞中不依赖 Ca2+ 的肌球蛋白 II 磷酸化和收缩。  |  Kolodney, MS., et al. 1999. J Physiol. 515 (Pt 1): 87-92. PMID: 9925880

订购信息

产品名称产品编号规格价格数量收藏夹

MYL12A/B 抗体 (A-10)

sc-376606
200 µg/ml
$316.00

MYL12A/B (A-10): m-IgG Fc BP-HRP 套装

sc-526039
200 µg Ab; 10 µg BP
$354.00

MYL12A/B (A-10): m-IgG2b BP-HRP 套装

sc-549666
200 µg Ab; 10 µg BP
$354.00

MYL12A/B 抗体 (A-10) AC

sc-376606 AC
500 µg/ml, 25% agarose
$416.00

MYL12A/B 抗体 (A-10) HRP

sc-376606 HRP
200 µg/ml
$316.00

MYL12A/B 抗体 (A-10) FITC

sc-376606 FITC
200 µg/ml
$330.00

MYL12A/B 抗体 (A-10) PE

sc-376606 PE
200 µg/ml
$343.00

MYL12A/B 抗体 (A-10) Alexa Fluor® 488

sc-376606 AF488
200 µg/ml
$357.00

MYL12A/B 抗体 (A-10) Alexa Fluor® 546

sc-376606 AF546
200 µg/ml
$357.00

MYL12A/B 抗体 (A-10) Alexa Fluor® 594

sc-376606 AF594
200 µg/ml
$357.00

MYL12A/B 抗体 (A-10) Alexa Fluor® 647

sc-376606 AF647
200 µg/ml
$357.00

MYL12A/B 抗体 (A-10) Alexa Fluor® 680

sc-376606 AF680
200 µg/ml
$357.00

MYL12A/B 抗体 (A-10) Alexa Fluor® 790

sc-376606 AF790
200 µg/ml
$357.00

MYL12A/B (A-10) 中和勝肽

sc-376606 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-376606 P appropriate for?

Asked by: Cweed
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Works well!Ho provato un free sample di questo anticorpo e funziona bene in diverse linee cellulari
Date published: 2021-10-21
Rated 5 out of 5 by from good antibodyI used 1:2000 for WB and 1:500 for ICC, and this antibody worked very good!
Date published: 2017-12-04
Rated 4 out of 5 by from Blown out bands seen in Western blot withBlown out bands seen in Western blot with BC3H1 and A-10 whole cell lysates -SCBT QC
Date published: 2015-02-27
Rated 5 out of 5 by from Beautiful cytoskeletal localization of stainingBeautiful cytoskeletal localization of staining in IF with methanol fixed HeLa cells -SCBT QC
Date published: 2014-08-01
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MYL12A/B 抗体 (A-10) is rated 4.5 out of 5 by 4.
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