Mitoxantrone Dihydrochloride CAS: 70476-82-3
MF: C22H28N4O6•2HCl
MW: 517.5
Induces DNA damage by intercalating into DNA and inhibiting Topo II.

Mitoxantrone Dihydrochloride (CAS 70476-82-3)

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同义词: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
应用; Induces DNA damage by intercalating into DNA and inhibiting Topo II
CAS号码: 70476-82-3
纯度: ≥99%
分子量: 517.5
分子式: C22H28N4O62HCl
* 参考分析证明 大量特定数据 (包括水 含量).
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Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.


参考文献

Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer: D. Faulds, et al.; Drugs 41, 400 (1991) Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells: A. Skladanowski & J. Konopa; Br. J. Cancer 82, 1300 (2000) A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol. 49, 145 (2002) A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences: B.S. Parker, et al.; J. Biol. Chem. 279, 18814 (2004)

物理状态 :
Solid
溶解度 :
Soluble in water (89 mg/ml at 25° C), 100% ethanol (slightly), methanol (slightly), and DMSO (89 mg/ml at 25° C). Insoluble in acetone.
保存 :
Store at -20° C
折射率 :
n20D ~1.71 (Predicted)
IC50 :
Type II topoisomerase : IC50 = 50 nM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
CB5748500
PubChem CID :
51082
默克索引 :
14: 6217
MDL 号码 :
MFCD00242943
EC号码 :
274-619-1
Beilstein 注册 :
4835931
SMILES :
C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl

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引用1 - 44

PMID: # 31272829  Fang, MY.|Markmiller, S.|Vu, AQ.|Javaherian, A.|Dowdle, WE.|Jolivet, P.|Bushway, PJ.|Castello, NA.|Baral, A.|Chan, MY.|Linsley, JW.|Linsley, D.|Mercola, M.|Finkbeiner, S.|Lecuyer, E.|Lewcock, JW.|Yeo, GW.| et al. 2019. Neuron.

PMID: # 28536462  Wani, A. et al. 2017. Sci Rep. 7: 2274.

PMID: # 25368983  Wallace, RA. et al. 2014. Anal. Chem. 86: 11819-25.

PMID: # 22555380  Wani, A. et al. 2012. Pharm. Res. 29: 2407-18.

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