Date published: 2025-9-5

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MeCP2 抗体 (G-6): sc-137070

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说明书
  • MeCP2 抗体 G-6 是小鼠单克隆 IgG3 κ,MeCP2抗体, 在8篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列187-486位于human物种的MeCP2的C-terminus附近
  • 推荐用于 mouse, rat 和 human 来源的MeCP2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-137070 X, 200 µg/0.1 ml)
  • 关于如何获取MeCP2 (G-6): sc-137070免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRPm-IgGκ BP-HRP是MeCP2抗体(G-6)在WB and IHC(P)应用中的首选二次检测试剂。这些试剂现在与MeCP2 抗体(G-6)捆绑销售(见下文订购信息)。

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関連項目

MeCP2抗体(G-6)是一种IgG3 κ小鼠单克隆MeCP2抗体(也称为甲基化CpG结合蛋白2抗体、MeCp-2蛋白抗体、甲基CpG结合蛋白2(Rett综合征)抗体、精神发育迟滞X连锁16抗体、精神发育迟滞X连锁79抗体、甲基CpG结合蛋白2抗体、Rett综合征抗体、AUTSX3抗体、MRXS13抗体、MRX16抗体、MRX79抗体、MRXSL抗体、PPMX抗体、RTS抗体或RTT抗体),可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类的MeCP2蛋白。MeCP2抗体(G-6)可作为非偶联的抗MeCP2抗体使用。DNA甲基化有助于调节哺乳动物和无脊椎动物系统中的基因转录。DNA甲基化主要发生在由5'胞嘧啶后接鸟嘌呤(CpG)组成的二核苷酸基序中存在的胞嘧啶残基上,并且需要DNA甲基转移酶的酶活性,这导致甲基化基因的转录抑制。已经鉴定出几种与甲基化CpG位点相关的蛋白质,包括甲基化CpG结合蛋白-1(MBD1)、MBD2、MBD3和MeCP2。MBD蛋白在体细胞组织中的表达量最高。MBD1以特定方式结合于富含甲基化CpG的域,并介导通常与DNA甲基化相关的转录抑制。类似地,MBD2通过与MeCP1阻遏物复合物中的组蛋白去乙酰化酶(HDAC1)结合来抑制甲基化基因的转录。另外,还被称为MED1的MBD4与错配修复蛋白MLH1结合,并优先结合于错配碱基对中的甲基化胞嘧啶残基。MeCP2以甲基化依赖性方式与染色体紧密结合,并与含有转录阻遏物mSin3A和组蛋白去乙酰化酶的核心阻遏物复合物结合。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MeCP2 抗体 (G-6) 参考文献:

  1. 小鼠和人类 Mbd1, Mbd2, Mbd3 和 Mbd4 基因的基因组结构和染色体图谱。  |  Hendrich, B., et al. 1999. Mamm Genome. 10: 906-12. PMID: 10441743
  2. 甲基-CpG结合蛋白MBD1同工酶在异染色质中介导的甲基化转录沉默。  |  Fujita, N., et al. 1999. Mol Cell Biol. 19: 6415-26. PMID: 10454587
  3. Rett 综合征中的 MECP2 缺失和基因型与表型的相关性。  |  Scala, E., et al. 2007. Am J Med Genet A. 143A: 2775-84. PMID: 17968969
  4. 神经元 MeCP2 的表观基因组综合分析揭示了其与活性基因之间长程相互作用的作用。  |  Yasui, DH., et al. 2007. Proc Natl Acad Sci U S A. 104: 19416-21. PMID: 18042715
  5. MeCP2 基因突变会导致突触发生和维持的急性和慢性缺陷的不同阶段。  |  Palmer, A., et al. 2008. Mol Cell Neurosci. 37: 794-807. PMID: 18295506
  6. MECP2 中的常见变异会带来系统性红斑狼疮的风险。  |  Sawalha, AH., et al. 2008. PLoS One. 3: e1727. PMID: 18320046
  7. DNA 甲基化通过甲基-CpG 结合蛋白间接抑制转录。  |  Boyes, J. and Bird, A. 1991. Cell. 64: 1123-34. PMID: 2004419
  8. 甲基 CpG 结合蛋白 MeCP2 的转录抑制涉及组蛋白去乙酰化酶复合物。  |  Nan, X., et al. 1998. Nature. 393: 386-9. PMID: 9620804
  9. 哺乳动物甲基-CpG 结合蛋白家族的鉴定和特征描述。  |  Hendrich, B. and Bird, A. 1998. Mol Cell Biol. 18: 6538-47. PMID: 9774669

订购信息

产品名称产品编号规格价格数量收藏夹

MeCP2 抗体 (G-6)

sc-137070
200 µg/ml
$316.00

MeCP2 (G-6): m-IgGκ BP-HRP 套装

sc-521414
200 µg Ab, 40 µg BP
$354.00

MeCP2 (G-6): m-IgG3 BP-HRP 套装

sc-550332
200 µg Ab; 40 µg BP
$354.00

MeCP2 抗体 (G-6) X

sc-137070 X
200 µg/0.1 ml
$316.00

怎样可以获取10uL小样?

Asked by: Sally Shang
感谢您的提问。如何获取免费试用装,请联系我们的技术支持部门。亚洲技术支持电话(+86) 021-60936350、邮箱asia@scbio.cn、或选择网页上Live Chat中的“中文支持”。 Thank you for your question. Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody. Our Asian Technical Service team is available at (+86) 021-60936350 or asia@scbio.cn or by live chat on our website.
Answered by: Technical Support 8
Date published: 2018-12-21

When should the TransCruz reagent sc-137070 X be used instead of the standard form sc-137070?

Asked by: Randy McDonald
Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from 功能很出色我一个月前购买了此产品,做了WB实验,抗体曝光效果不错,特异性强,没发现非特异性条带,感觉抗体质量不错。
Date published: 2017-11-28
Rated 1 out of 5 by from multiple bandsThis antibody is no good. It binds to multiple bands and is useful for very few purposes. The 20700 antibody was quite good. Why would you discontinue it!?
Date published: 2017-03-15
Rated 5 out of 5 by from great abWe have carried out an extensive comparison to our home-made anti-MeCP2 antibodies, both by IF and WB, and this is great
Date published: 2017-02-06
Rated 5 out of 5 by from Band detected at expected mw in Jurkat and KBand detected at expected mw in Jurkat and K-562 nuclear extracts. -SCBT QC
Date published: 2015-07-05
Rated 5 out of 5 by from Robust staining in paraffinRobust staining in paraffin-embedded human brain. -SCBT QC
Date published: 2015-03-04
Rated 3 out of 5 by from Worked well with human recombinant MeCP2Worked well with human recombinant MeCP2 fusion protein by WB -SCBT QC
Date published: 2015-02-20
Rated 5 out of 5 by from ICC publishable data with mouse cerebralICC publishable data with mouse cerebral hemisphere - SCBT Publication Review
Date published: 2015-01-06
Rated 5 out of 5 by from Great immunofluorescence nuclear stainingGreat immunofluorescence nuclear staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2013-02-12
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MeCP2 抗体 (G-6) is rated 4.3 out of 5 by 8.
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