MCI-186 CAS: 89-25-8
MF: C10H10N2O
MW: 174.20
A free radical scavenger that enhances NGF protein levels via the JNK pathway.

MCI-186 (CAS 89-25-8)

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同义词: 3-Methyl-1-phenyl-2-pyrazolin-5-one; Edaravone; NSC 2629
应用; A free radical scavenger that enhances NGF protein levels via the JNK pathway
CAS号码: 89-25-8
纯度: ≥98%
分子量: 174.20
分子式: C10H10N2O
* 参考分析证明 大量特定数据 (包括水 含量).
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MCI-186, also known as 3-methyl-1-phenyl-2-pyrazolin-5-one, is a free radical scavenger that has been shown to contain protective properties towards murine brain ischemia. In vitro this compound has been reported to decrease cell death in murine models. Mechanistic studies suggest that MCI-186 enhances neuronal growth factor (NGF) protein levels which are essential for neuronal growth and survival. Furthermore, the enhancement of NGF expression in astrocytes has been thought to be done via the c-Jun N-terminal Kinase (JNK) pathway.


参考文献

1. Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281: 921-927. PMID: 9152402
2. Zhou, F., et al. 2009. Brain Inj. 23: 353-357. PMID: 19330597
3. Lee, B.J., et al. 2010. Brain Res. 1307: 22-27. PMID: 19840779
4. Yoshida, H., et al. 2010. Neurosci. Res. 66: 284-289. PMID: 19954754

物理状态 :
Solid
溶解度 :
Soluble in water (3.3 g/L) at 20° C, DMSO (~30 mg/ml), methanol, ethanol (~15 mg/ml), DMF (~50 mg/ml), and a 1:9 solution of DMF:PBS(pH7.2) (~0.1 mg/ml).
保存 :
Store at room temperature
熔点 :
126-128° C (lit.)
沸点 :
287° C at 265 mmHg
密度 :
1.12 g/cm3 at 20° C
折射率 :
n20D 1.61
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
1
RTECS :
UQ9625000
PubChem CID :
4021
默克索引 :
14: 6713
MDL 号码 :
MFCD00003138
EC号码 :
201-891-0
Beilstein 注册 :
609575
SMILES :
CC1=NN(C(=O)C1)C2=CC=CC=C2

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