MAP-1S Antibody (4H2): sc-517081

MAP-1S Antibody (4H2) is a mouse monoclonal IgG2a kappa light chain antibody that detects MAP-1S protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-MAP-1S antibody (4H2) is available as a non-conjugated isotype antibody. MAP-1S protein, also known as microtubule-associated protein 1S, plays a crucial role in forming microtubule bundles, which are essential for maintaining cellular structure and facilitating intracellular transport. MAP-1S protein is part of the microtubule-associated protein family and stabilizes microtubules, influencing their dynamics and organization within cells. MAP-1S protein is expressed in various tissues, including cerebral cortex, testis, brain, heart, colon, kidney, liver, lung, placenta, spleen, stomach, small intestine, and neurons, highlighting MAP-1S protein′s importance in both structural integrity and cellular function across different biological systems. Through localization to both nucleus and cytoplasm, MAP-1S protein contributes to spatial organization of microtubules, which is vital for processes such as cell division, intracellular transport, and maintenance of cell shape.

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MAP-1S Antibody (4H2) References:

1. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity.  |  Liu, L. and McKeehan, WL. 2002. Genomics. 79: 124-36. PMID: 11827465
2. Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells.  |  Liu, L., et al. 2002. In Vitro Cell Dev Biol Anim. 38: 582-94. PMID: 12762840
3. Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein.  |  Wong, EY., et al. 2004. Biol Reprod. 70: 775-84. PMID: 14627543
4. RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics.  |  Dallol, A., et al. 2004. Cancer Res. 64: 4112-6. PMID: 15205320
5. Microtubule-associated protein 8 contains two microtubule binding sites.  |  Ding, J., et al. 2006. Biochem Biophys Res Commun. 339: 172-9. PMID: 16297881
6. Depletion of the Ras association domain family 1, isoform A-associated novel microtubule-associated protein, C19ORF5/MAP1S, causes mitotic abnormalities.  |  Dallol, A., et al. 2007. Cancer Res. 67: 492-500. PMID: 17234756
7. The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain.  |  Eriksson, M., et al. 2007. Biochem Biophys Res Commun. 361: 127-32. PMID: 17658481

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MAP-1S Antibody (4H2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MAP-1S Antibody (4H2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MAP-1S Antibody (4H2) Specifications

Alternate Product Name: MAP-1S

Product Clone Name: 4H2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 929-1026

Epitope Target: MAP-1S

Epitope Species: human

Product Reactivity/Detection: MAP-1S

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MAP-1S Antibody (4H2): N/A