Molecular structure of Levovirin, CAS Number: 206269-27-4
Levovirin (CAS 206269-27-4)
Alternate Names:
1-β-L-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
CAS Number:
206269-27-4
Molecular Weight:
244.2
Molecular Formula:
C8H12N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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This compound falls under the category of triazole ribonucleosides and ribonucleotides, which are nucleoside derivatives featuring a ribose (or deoxyribose) unit glycosylated to a triazole. Nucleotides, on the other hand, possess a phosphate group connected to the C5 carbon of the ribose (or deoxyribose) moiety. Levovirin, a monocyclic L-nucleoside, possesses type 1 cytokine-inducing properties. It is the L-enantiomer of Ribavirin, exhibiting comparable immunomodulatory effects, yet lacking direct antiviral activity or causing hemolytic anemia.
Levovirin (CAS 206269-27-4) References
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- Absorption, pharmacokinetics and excretion of levovirin in rats, dogs and cynomolgus monkeys. | Lin, CC., et al. 2003. J Antimicrob Chemother. 51: 93-9. PMID: 12493792
- New developments in the treatment of hepatitis C. | Rossi, SJ. and Wright, TL. 2003. Gut. 52: 756-7. PMID: 12692065
- Effect of ribavirin, levovirin and viramidine on liver toxicological gene expression in rats. | Fang, C., et al. 2003. J Appl Toxicol. 23: 453-9. PMID: 14635270
- Suppression of haematopoiesis during therapy of chronic hepatitis C with different interferon alpha mono and combination therapy regimens. | Schmid, M., et al. 2005. Gut. 54: 1014-20. PMID: 15951552
- Transport of levovirin prodrugs in the human intestinal Caco-2 cell line. | Li, F., et al. 2006. J Pharm Sci. 95: 1318-25. PMID: 16634069
- Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy. | Hofmann, WP., et al. 2007. Gastroenterology. 132: 921-30. PMID: 17383421
- Analysis of ribavirin mutagenicity in human hepatitis C virus infection. | Chevaliez, S., et al. 2007. J Virol. 81: 7732-41. PMID: 17494069
- Therapeutically targeting RNA viruses via lethal mutagenesis. | Graci, JD. and Cameron, CE. 2008. Future Virol. 3: 553-566. PMID: 19727424
- Effect of ribavirin on the frequency of RNase L cleavage sites within the hepatitis C viral genome. | Mihm, U., et al. 2010. J Viral Hepat. 17: 217-21. PMID: 19758279
- Structural modeling of the NS 3 helicase of Tick-borne encephalitis virus and their virtual screening of potent drugs using molecular docking. | Singh, V. and Somvanshi, P. 2009. Interdiscip Sci. 1: 168-72. PMID: 20640834
- Mechanism of action of ribavirin in the treatment of chronic hepatitis C. | Te, HS., et al. 2007. Gastroenterol Hepatol (N Y). 3: 218-25. PMID: 21960835
- Comparison of the chronic effects of ribavirin and caffeic acid phenethyl ester (CAPE) on pancreatic damage and hepatotoxicity. | Motor, S., et al. 2014. Int J Clin Exp Med. 7: 1005-13. PMID: 24955174
- Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS. | Garrison, KL., et al. 2015. J Pharm Sci. 104: 3229-35. PMID: 26010239
- Supramolecular Self-Assembly Built by Weak Hydrogen, Chalcogen, and Unorthodox Nonbonded Motifs in 4-(4-Chlorophenyl)-3-[(4-fluorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole, a Selective COX-2 Inhibitor: Insights from X-ray and Theoretical Studies. | Al-Wahaibi, LH., et al. 2021. ACS Omega. 6: 6996-7007. PMID: 33748613
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Levovirin, 10 mg | sc-488869 | 10 mg | $439.00 |