Date published: 2025-9-6

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LAMP1 抗体 (H5G11): sc-18821

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说明书
  • LAMP1抗体(H5G11)是小鼠单克隆IgG1 κ, 在93篇文献中引用,规格为200 µg/ml
  • 对human来源的脾脏细胞的抗性
  • LAMP1 抗体 (H5G11) 推荐用于WB, IP, IF 和 IHC(P),检测human 来源的 LAMP-1
  • 抗LAMP1抗体(H5G11)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取LAMP1 (H5G11): sc-18821免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG1 BP-HRP 是 LAMP1 抗体 (H5G11) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与LAMP1 抗体 (H5G11) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

LAMP-1抗体(H5G11)是一种小鼠单克隆IgG1κ轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和免疫组织化学检测人类LAMP-1。抗LAMP-1抗体(H5G11)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。LAMP-1,也称为CD107a,是一种糖基化的一型膜蛋白,主要位于溶酶体和晚期内质网表面,在细胞粘附和溶酶体酶的运输等细胞过程中发挥着关键作用。LAMP-1存在于活化血小板表面,表明其在这些细胞的粘附性和促血栓性方面具有重要作用,而这对伤口愈合和止血至关重要。此外,LAMP-1还参与维持溶酶体的酸度和保护溶酶体膜免受自消化,在溶酶体贮积症中,LAMP-1的表达水平会升高,这凸显了LAMP-1在细胞稳态和疾病状态中的重要性。LAMP-1独特的分选和运输机制以及它与其他溶酶体蛋白的相互作用凸显了LAMP-1在细胞功能和病理学中的关键作用,这使得LAMP-1单克隆抗体(H5G11)成为研究人员研究溶酶体动力学和相关疾病的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

LAMP1 抗体 (H5G11) 参考文献:

  1. 在诱导凋亡的人胶质母细胞瘤细胞系中,Lamp-1上调。  |  Chen, JW., et al. 2001. J Biomed Sci. 8: 365-74. PMID: 11455200
  2. CD107a(LAMP-1)的免疫化学分析。  |  Parkinson-Lawrence, EJ., et al. 2005. Cell Immunol. 236: 161-6. PMID: 16168398
  3. 溶酶体相关膜蛋白1(LAMP-1)在阿尔茨海默病中的作用。  |  Barrachina, M., et al. 2006. Neuropathol Appl Neurobiol. 32: 505-16. PMID: 16972884
  4. 星形细胞瘤中溶酶体相关膜蛋白-1(LAMP-1)的表达。  |  Jensen, SS., et al. 2013. Int J Clin Exp Pathol. 6: 1294-305. PMID: 23826410
  5. 表面CD107a/LAMP-1可保护自然杀伤细胞免受脱颗粒相关损伤。  |  Cohnen, A., et al. 2013. Blood. 122: 1411-8. PMID: 23847195
  6. FUT1对LAMP-1和LAMP-2的富集作用与乳腺癌细胞的溶酶体定位和自噬通量相关。  |  Tan, KP., et al. 2016. Cell Death Dis. 7: e2347. PMID: 27560716
  7. 主要溶酶体膜蛋白 LAMP-1 和 LAMP-2 参与 C2C12 肌母细胞的分化  |  Sakane, H. and Akasaki, K. 2018. Biol Pharm Bull. 41: 1186-1193. PMID: 30068868
  8. E3泛素连接酶RNF13通过促进LAMP-1蛋白酶体降解来抑制TLR溶酶体降解。  |  Liu, W., et al. 2024. Adv Sci (Weinh). 11: e2309560. PMID: 39031743
  9. Lamp-1不具有F9细胞特有的大聚乳酸胺聚糖。  |  Romero, PA., et al. 1993. Biochem J. 296 (Pt 1): 253-7. PMID: 8250851
  10. 人类肿瘤细胞中 Lamp-1 和 Lamp-2 的表达及其与 galectin-3 的相互作用。  |  Sarafian, V., et al. 1998. Int J Cancer. 75: 105-11. PMID: 9426697

订购信息

产品名称产品编号规格价格数量收藏夹

LAMP1 抗体 (H5G11)

sc-18821
200 µg/ml
$316.00

LAMP1 (H5G11): m-IgG1 BP-HRP 套装

sc-531640
200 µg Ab; 20 µg BP
$354.00

LAMP1 抗体 (H5G11) AC

sc-18821 AC
500 µg/ml, 25% agarose
$416.00

LAMP1 抗体 (H5G11) HRP

sc-18821 HRP
200 µg/ml
$316.00

LAMP1 抗体 (H5G11) FITC

sc-18821 FITC
200 µg/ml
$330.00

LAMP1 抗体 (H5G11) PE

sc-18821 PE
200 µg/ml
$343.00

LAMP1 抗体 (H5G11) Alexa Fluor® 488

sc-18821 AF488
200 µg/ml
$357.00

LAMP1 抗体 (H5G11) Alexa Fluor® 546

sc-18821 AF546
200 µg/ml
$357.00

LAMP1 抗体 (H5G11) Alexa Fluor® 594

sc-18821 AF594
200 µg/ml
$357.00

LAMP1 抗体 (H5G11) Alexa Fluor® 647

sc-18821 AF647
200 µg/ml
$357.00

LAMP1 抗体 (H5G11) Alexa Fluor® 680

sc-18821 AF680
200 µg/ml
$357.00

LAMP1 抗体 (H5G11) Alexa Fluor® 790

sc-18821 AF790
200 µg/ml
$357.00

What is the epitope recognized by LAMP-1 Antibody (H5G11): sc-18821?

Asked by: cjMara
LAMP-1 Antibody (H5G11) is a mouse monoclonal raised against adherent spleen cells of human origin. The exact epitope has not been determined.
Answered by: Technical Support 13
Date published: 2017-01-09
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Rated 5 out of 5 by from anti-LAMP1It works beautifully for immunofluorescence for HEK293 cells
Date published: 2019-01-13
Rated 5 out of 5 by from super fonctionnalitéstrès bon marquage des lysosomes sur cellules MCF7 utilisé au 1/50 ( peut être dilué plus )
Date published: 2018-01-30
Rated 5 out of 5 by from Just a great product !!Strong data for all applications; much better product than any of the discontiued polyclonals
Date published: 2017-01-26
Rated 5 out of 5 by from Great Antibody for IFThis antibody is well-cited for a variety of applications including WB, IP, IF, and even IHC. Strong, clear signal with little to no background. Beautiful IF staining.
Date published: 2017-01-09
Rated 4 out of 5 by from Good resultgood published result in western bloting(1:500)of lot number C1413.
Date published: 2016-12-16
Rated 5 out of 5 by from Used on a regular basis and published as wellUsed on a regular basis and published as well. They are working great for us.
Date published: 2015-05-28
Rated 5 out of 5 by from Good cytoplasmic and membrane staining inGood cytoplasmic and membrane staining in IF in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-04-21
Rated 5 out of 5 by from Strong cytoplasmic staining of glandularStrong cytoplasmic staining of glandular cells in formalin-fixed human adrenal gland in IHC. -SCBT QC
Date published: 2015-04-03
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LAMP1 抗体 (H5G11) is rated 4.9 out of 5 by 11.
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