Lamin B1 Antibody (119D5-F1): sc-56143
- Lamin B1 Antibody (119D5-F1) is a mouse monoclonal IgG1, cited in 26 publications, provided at 50 µg/0.5 ml
- raised against lamins purified from liver of rat origin
- recommended for detection of Lamin B1 of mouse, rat, human, bovine and canine origin by WB, IP, IF, FCM and ELISA
- See Lamin B1 (A-11): sc-377000 for Lamin B1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Lamin B1 Antibody (119D5-F1). This work is in progress.
Lamin B1 Antibody (119D5-F1) is a mouse monoclonal IgG1 antibody that detects Lamin B1 in mouse, rat, human, bovine, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Lamin B1 is a crucial component of the nuclear lamina, a fibrous structure that provides mechanical support to the nuclear envelope and plays a significant role in maintaining nuclear integrity and cellular morphology. Lamin B1 is essential for chromatin organization and gene expression regulation, as Lamin B1 interacts with various nuclear proteins and chromatin, influencing cellular processes such as DNA replication and repair. Notably, Lamin B1 undergoes post-translational modifications, including farnesylation and phosphorylation, which are vital for function and stability. Mutations in the gene encoding Lamin B1 have been linked to autosomal dominant adult-onset leukodystrophy (ADLD), a neurodegenerative disorder characterized by cerebellar dysfunction and demyelination of the central nervous system, underscoring Lamin B1′s importance in both cellular health and disease. Anti-Lamin B1 antibody (119D5-F1) is an invaluable tool for researchers studying nuclear envelope dynamics and Lamin B1′s implications in various pathologies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lamin B1 Antibody (119D5-F1) | sc-56143 | 50 µg/0.5 ml | $322.00 |