Molecular structure of Lactosyl Ceramide, CAS Number: 4682-48-8
Lactosyl Ceramide (CAS 4682-48-8)
Alternate Names:
Ceramide β-lactoside
Application:
Lactosyl Ceramide is an inducer of Ras-GTP loading, MEK and Raf kinases, p44 MAP kinase, c-fos expression
CAS Number:
4682-48-8
Purity:
≥98%
Molecular Weight:
960.4
Molecular Formula:
C53H101NO13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Lactosyl ceramide is a glycosphingolipid that plays a pivotal role in cellular processes, acting as a key component of cell membranes and participating in signal transduction pathways. Lactosyl ceramide is involved in various biological functions, including cell-cell recognition, adhesion, and the modulation of cell growth and differentiation. Lactosyl ceramide is integral to studying the structure and dynamics of cell membranes. It contributes to membrane microdomains (lipid rafts) that are critical for signal transduction and cellular communication. Given the abundance of glycosphingolipids in the nervous system, Lactosyl ceramide is of interest in neuroscience research.
Lactosyl Ceramide (CAS 4682-48-8) References
- Abnormalities in the glycosphingolipid content of human Pk and p erythrocytes. | Marcus, DM., et al. 1976. Proc Natl Acad Sci U S A. 73: 3263-7. PMID: 1067617
- The binding of Proteus mirabilis nonagglutinating fimbriae to ganglio-series asialoglycolipids and lactosyl ceramide. | Lee, KK., et al. 2000. Can J Microbiol. 46: 961-6. PMID: 11068685
- Galactose to ceramide linkage is essential for the binding of a polyclonal antibody to galactosyl ceramide. | Bhat, S. 1992. J Neuroimmunol. 41: 105-10. PMID: 1460087
- Developmental patterns of ganglioside sialosylation coincident with neuritogenesis in cultured embryonic chick brain neurons. | Rosenberg, A., et al. 1992. J Biol Chem. 267: 10607-12. PMID: 1587841
- Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type 1 envelope glycoprotein gp120. | Bhat, S., et al. 1991. Proc Natl Acad Sci U S A. 88: 7131-4. PMID: 1871126
- Synthesis of cerebroside, lactosyl ceramide, and ganglioside GM3 analogs containing beta-thioglycosidically linked ceramide. | Hasegawa, A., et al. 1991. Carbohydr Res. 214: 43-53. PMID: 1954633
- Immunological discrimination of intralysosomal, cytosolic, and two membrane sialidases present in rat tissues. | Miyagi, T., et al. 1990. J Biochem. 107: 794-8. PMID: 2398043
- Application of monoclonal antibody KH2 against lactosyl and neolactotetraosyl ceramide to immunohistochemical study of human cancers. | Hinoda, Y., et al. 1989. Tumour Biol. 10: 268-74. PMID: 2554480
- Glycolipid sialosyltransferase activity in synaptosomes exhibits a product specificity for (2-8)disialosyl lactosyl ceramide (ganglioside GD3). | Durrie, R., et al. 1987. J Neurosci Res. 18: 456-65. PMID: 2830410
- A long chain spin label for glycosphingolipid studies: transbilayer fatty acid interdigitation of lactosyl ceramide. | Grant, CW., et al. 1987. Biochim Biophys Acta. 902: 169-77. PMID: 3040094
- A natural inhibitor of sialyl transferase and its possible influence on this enzyme activity during brain development. | Duffard, RO. and Caputto, R. 1972. Biochemistry. 11: 1396-400. PMID: 5021596
- Turnover in vivo of lactosyl-ceramide and other glycosphingolipids in the adult rat brain. | Barkai, AI. 1981. J Neurochem. 36: 317-20. PMID: 7463058
- Adhesion of S-fimbriated Escherichia coli to brain glycolipids mediated by sfaA gene-encoded protein of S-fimbriae. | Prasadarao, NV., et al. 1993. J Biol Chem. 268: 10356-63. PMID: 8098039
- The reactions of antibodies to paragloboside (lacto-N-neotetraosyl ceramide) with human erythrocytes and lymphocytes. | Schwarting, GA. and Marcus, DM. 1977. J Immunol. 118: 1415-9. PMID: 850070
- Molecular forces between membranes displaying neutral glycosphingolipids: evidence for carbohydrate attraction. | Yu, ZW., et al. 1998. Biochemistry. 37: 1540-50. PMID: 9484224
Activator of:
Enzyme, and ERK 1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lactosyl Ceramide, 1 mg | sc-204051 | 1 mg | $243.00 |